BIO - CAS 667463-62-9
Catalog number: 667463-62-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
BIO (6-bromoindirubin-3'-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.
BIO; ​GSK3 Inhibitor IX; MLS 2052; MLS-2052; MLS2052.
Canonical SMILES:
1.A novel pyrene based fluorescent probe for selective detection of cysteine in presence of other bio-thiols in living cells.
Rani BK1, John SA2. Biosens Bioelectron. 2016 Apr 7;83:237-242. doi: 10.1016/j.bios.2016.04.013. [Epub ahead of print]
This manuscript reports the synthesis of pyrene-based fluorescent probe (PA-1) containing α,β-unsaturated carbonyl moiety and its application towards the selective and sensitive detection of cysteine (Cys) over other bio-thiols. The probe, 3-(2-hydroxyphenyl)-1-pyrenyl-2-propenone (PA-1) was synthesized through Claisen-Schmidt condensation between acetyl pyrene and salicylaldehyde. The formed product was characterized by 1H NMR, 13C NMR and GC-MS techniques. The probe exhibited absorption maximum at 374nm and emission maximum at 467nm (λex=342nm). The emission intensity of PA-1 was greatly enhanced while adding 2.5nM Cys. This can be attributed to the nucleophilic attack of Cys to the α,β-unsaturated ketone resulting in switching off, intramolecular charge transfer (ICT) from pyrene moiety to the phenolic nucleus. This was confirmed by DFT measurements. The PA-1 exhibited an excellent selectivity towards the determination of 40nM cys in the presence of 250,000-fold higher concentration of common interferents.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related CDK Products

CAS 700-06-1 Indole-3-carbinol

(CAS: 700-06-1)

Indole-3-carbinol is an inhibitor of cell growth via suppressing incorporation of [3H]thymidine, triggering G1 cell cycle arrest and downregulation of cyclin-de...

CAS 1204918-72-8 SB1317

(CAS: 1204918-72-8)

SB1317 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. It dose-dependently inhibits signaling pathways downstream of CDKs, JAK2 and FLT3 in cancer cel...

CAS 1092443-52-1 BS181

(CAS: 1092443-52-1)

BS-181 is a highly selective CDK inhibitor for CDK7 with an IC(50) of 21 nmol/L. Testing of other CDKs as well as another 69 kinases showed that BS-181 only inh...

CAS 942425-68-5 PHA-767491 hydrochloride

PHA-767491 hydrochloride
(CAS: 942425-68-5)

PHA-767491 hydrochloride is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor, which prevents initiation of DNA replication. It inhibits cell proliferation in ...

CAS 920113-03-7 Riviciclib HCl

Riviciclib HCl
(CAS: 920113-03-7)

Riviciclib, also known as P276-00, is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. P276-00 selectively binds to and ...

CAS 582315-72-8 BMS-265246

(CAS: 582315-72-8)

BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM. It is 25-fold more selective for CDK1/2 than CDK4.

CAS 496864-16-5 Aloisine A

Aloisine A
(CAS: 496864-16-5)

Aloisine a is a cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases...

CAS 377090-84-1 SU9516

(CAS: 377090-84-1)

SU 9516 is a potent, selective cdk2 inhibitor (IC50 values are 0.022, 0.04, >10, >10, 18 and >100 μM for cdk2, cdk1, cdk4, PKC, p38, PDGFR and EGFR respectively...

Chemical Structure

CAS 667463-62-9 BIO

Quick Inquiry

Verification code

Featured Items