BIO - CAS 667463-62-9
Catalog number: 667463-62-9
Category: Inhibitor
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Molecular Formula:
C16H10BrN3O2
Molecular Weight:
356.17
COA:
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Targets:
CDK
Description:
BIO (6-bromoindirubin-3'-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.
Purity:
>98%
Synonyms:
BIO; ​GSK3 Inhibitor IX; MLS 2052; MLS-2052; MLS2052.
MSDS:
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InChIKey:
WNWSUJQVZJJGLF-UHFFFAOYSA-N
InChI:
InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,20,22H,(H,19,21)
Canonical SMILES:
C1=CC2=C(C(=C3C4=C(C=C(C=C4)Br)NC3=O)N=C2C=C1)NO
1.A novel pyrene based fluorescent probe for selective detection of cysteine in presence of other bio-thiols in living cells.
Rani BK1, John SA2. Biosens Bioelectron. 2016 Apr 7;83:237-242. doi: 10.1016/j.bios.2016.04.013. [Epub ahead of print]
This manuscript reports the synthesis of pyrene-based fluorescent probe (PA-1) containing α,β-unsaturated carbonyl moiety and its application towards the selective and sensitive detection of cysteine (Cys) over other bio-thiols. The probe, 3-(2-hydroxyphenyl)-1-pyrenyl-2-propenone (PA-1) was synthesized through Claisen-Schmidt condensation between acetyl pyrene and salicylaldehyde. The formed product was characterized by 1H NMR, 13C NMR and GC-MS techniques. The probe exhibited absorption maximum at 374nm and emission maximum at 467nm (λex=342nm). The emission intensity of PA-1 was greatly enhanced while adding 2.5nM Cys. This can be attributed to the nucleophilic attack of Cys to the α,β-unsaturated ketone resulting in switching off, intramolecular charge transfer (ICT) from pyrene moiety to the phenolic nucleus. This was confirmed by DFT measurements. The PA-1 exhibited an excellent selectivity towards the determination of 40nM cys in the presence of 250,000-fold higher concentration of common interferents.
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CAS 667463-62-9 BIO

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