BIO - CAS 667463-62-9
Catalog number: 667463-62-9
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
BIO (6-bromoindirubin-3'-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.
BIO; ​GSK3 Inhibitor IX; MLS 2052; MLS-2052; MLS2052.
Canonical SMILES:
1.A novel pyrene based fluorescent probe for selective detection of cysteine in presence of other bio-thiols in living cells.
Rani BK1, John SA2. Biosens Bioelectron. 2016 Apr 7;83:237-242. doi: 10.1016/j.bios.2016.04.013. [Epub ahead of print]
This manuscript reports the synthesis of pyrene-based fluorescent probe (PA-1) containing α,β-unsaturated carbonyl moiety and its application towards the selective and sensitive detection of cysteine (Cys) over other bio-thiols. The probe, 3-(2-hydroxyphenyl)-1-pyrenyl-2-propenone (PA-1) was synthesized through Claisen-Schmidt condensation between acetyl pyrene and salicylaldehyde. The formed product was characterized by 1H NMR, 13C NMR and GC-MS techniques. The probe exhibited absorption maximum at 374nm and emission maximum at 467nm (λex=342nm). The emission intensity of PA-1 was greatly enhanced while adding 2.5nM Cys. This can be attributed to the nucleophilic attack of Cys to the α,β-unsaturated ketone resulting in switching off, intramolecular charge transfer (ICT) from pyrene moiety to the phenolic nucleus. This was confirmed by DFT measurements. The PA-1 exhibited an excellent selectivity towards the determination of 40nM cys in the presence of 250,000-fold higher concentration of common interferents.
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CAS 667463-62-9 BIO

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