Binimetinib - CAS 606143-89-9
Catalog number:
606143-89-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
MEK
Description:
Binimetinib is an oral, highly selective MEK inhibitor.
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
MEK-162; MEK162; ARRY-162; ARRY162; ARRY 162; ARRY-438162
MSDS:
Inquire
Current Developer:
Array Biopharm./Novartis.
1.Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression.
Woodfield SE1, Zhang L2, Scorsone KA3, Liu Y4,5, Zage PE6,7. BMC Cancer. 2016 Mar 1;16(1):172. doi: 10.1186/s12885-016-2199-z.
BACKGROUND: Novel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition with the novel MEK1/2 inhibitor binimetinib would be effective in neuroblastoma preclinical models.
2.A phase I study of binimetinib (MEK162) in Japanese patients with advanced solid tumors.
Watanabe K1,2, Otsu S3, Hirashima Y3, Morinaga R3, Nishikawa K3, Hisamatsu Y3, Shimokata T4, Inada-Inoue M4, Shibata T4, Takeuchi H5, Watanabe T6, Tokushige K7, Maacke H8, Shiaro K3, Ando Y4. Cancer Chemother Pharmacol. 2016 Apr 12. [Epub ahead of print]
PURPOSE: Binimetinib is a potent, selective MEK1/2 inhibitor with demonstrated efficacy against BRAF- and RAS-mutant tumors. Retinal adverse events associated with MEK inhibitors have been reported in some cases. The aim of this study was to assess single-agent binimetinib, with detailed ophthalmologic monitoring, in Japanese patients with advanced solid tumors.
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CAS 606143-89-9 Binimetinib

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