Binimetinib - CAS 606143-89-9
Catalog number: B0084-455720
Category: Inhibitor
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Binimetinib is an oral, highly selective MEK inhibitor.
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B0084-455720 300 mg $499 In stock
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MEK162; MEK-162; MEK 162; ARRY162; ARRY-162; ARRY 162; ARRY438162, Binimetinib; 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
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Array Biopharm./Novartis.
1.Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression.
Woodfield SE1, Zhang L2, Scorsone KA3, Liu Y4,5, Zage PE6,7. BMC Cancer. 2016 Mar 1;16(1):172. doi: 10.1186/s12885-016-2199-z.
BACKGROUND: Novel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition with the novel MEK1/2 inhibitor binimetinib would be effective in neuroblastoma preclinical models.
2.A phase I study of binimetinib (MEK162) in Japanese patients with advanced solid tumors.
Watanabe K1,2, Otsu S3, Hirashima Y3, Morinaga R3, Nishikawa K3, Hisamatsu Y3, Shimokata T4, Inada-Inoue M4, Shibata T4, Takeuchi H5, Watanabe T6, Tokushige K7, Maacke H8, Shiaro K3, Ando Y4. Cancer Chemother Pharmacol. 2016 Apr 12. [Epub ahead of print]
PURPOSE: Binimetinib is a potent, selective MEK1/2 inhibitor with demonstrated efficacy against BRAF- and RAS-mutant tumors. Retinal adverse events associated with MEK inhibitors have been reported in some cases. The aim of this study was to assess single-agent binimetinib, with detailed ophthalmologic monitoring, in Japanese patients with advanced solid tumors.
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