Bimolane - CAS 74550-97-3
Catalog number:
74550-97-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H32 N6 O6
Molecular Weight:
452.51
COA:
Inquire
Targets:
Topoisomerase
Description:
Bimolane is a topoisomerase II inhibitor. It has been widely used as an anti-neoplastic agent and for the treatment of psoriasis in China. Bimolane is also a leukemogenic agent and is thought to exert its effects through the inhibition of topoisomerase II.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
Bimolane;4,4'-Ethylenebis[1-(morpholinomethyl)-2,6-piperazinedione];AT-1727
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
psoriasis
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
JGQGCJKPBAYEHO-UHFFFAOYSA-N
InChI:
1S/C20H32N6O6/c27-17-11-23(12-18(28)25(17)15-21-3-7-31-8-4-21)1-2-24-13-19(29)26(20(30)14-24)16-22-5-9-32-10-6-22/h1-16H2
Canonical SMILES:
N1(C(CN(CC1=O)CCN1CC(=O)N(C(C1)=O)CN1CCOCC1)=O)CN1CCOCC1
1.A comparative study of the cytotoxic and genotoxic effects of ICRF-154 and bimolane, two catalytic inhibitors of topoisomerase II.
Vuong MC1, Hasegawa LS, Eastmond DA. Mutat Res. 2013 Jan 20;750(1-2):63-71. doi: 10.1016/j.mrgentox.2012.09.005. Epub 2012 Sep 21.
ICRF-154 and bimolane have been used for the treatment of cancer, psoriasis, and uveitis in humans. Previous reports have revealed that the two drugs are topoisomerase II catalytic inhibitors, and patients treated with these agents have developed unique types of secondary leukemia. A study published in 1984 by Camerman and colleagues proposed that the therapeutic effects of bimolane could be due to ICRF-154, an impurity present within the bimolane samples that may also be responsible for the toxic effects attributed to bimolane. To date, this hypothesis has not been evaluated. In addition, little is known about the potential cytotoxic and genotoxic effects of ICRF-154. In this study, a combination of in vitro tests in human TK6 lymphoblastoid cells has been used to characterize the cytotoxic and genotoxic effects of ICRF-154 and bimolane as well as to compare the results for the two chemicals. ICRF-154 and bimolane were both cytotoxic, exhibiting very similar effects in three measures of cytotoxicity and cell proliferation.
2.Translocation t(7;11)(P15;P15) in a patient with therapy-related acute myeloid leukemia following bimolane and ICRF-154 treatment for psoriasis.
Xue Y1, Guo Y, Xie X. Leuk Res. 1997 Feb;21(2):107-9.
The t(7;11)(p15;p15) translocation is an uncommon balanced aberration which has been found predominantly in Orientals, frequently presenting as de novo acute myeloid leukemia (AML) and occasionally as chronic myeloid leukemia in blastic crisis. This paper reports the first case of therapy-related AML (t-AML) with t(7;11). The patient was a 36-year-old Chinese man with a longstanding psoriasis for which he had received bimolane and ICRF-154 therapy. His cytology and cytochemistry were compatible with M2 subtype of AML. He achieved a complete remission after two courses of HA regimen (homoharringtonine and Ara-c). Six months later, he relapsed and died of overwhelming infection after 3 months. Chromosome analysis on bone marrow cells using short-term culture and R-banding at presentation revealed his karyotype to be 46,XY,t(7;11)(p15;p15)/ 46,XY,t(7;11)(p15;p15),del(12)(p12)/ 46,XY. This case implies: (1) dioxopiperazine derivatives can induce AML with t(7;11) in addition to inducing AML with t(15;17) or t(8;21); (2) t(7;11) may be found not only in de novo AML, but also in t-AML.
3.[Mutagenic effects of bimolane].
Chen SQ1, Xue KX, Wu JZ, Ma GJ. Zhongguo Yao Li Xue Bao. 1995 Nov;16(6):531-3.
AIM: To study the genotoxicity of bimolane.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Topoisomerase Products


CAS 4707-32-8 β-Lapachone

β-Lapachone
(CAS: 4707-32-8)

β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae), exhibiting anti-inflammatory properties by suppr...

CAS 211100-13-9 Sabarubicin

Sabarubicin
(CAS: 211100-13-9)

Sabarubicina, a disaccharide analogue of doxorubicin, is an antineoplastic agent which can intercalate into the DNA of tumor cells and interact with topoisomera...

CAS 70476-82-3 Mitoxantrone HCl

Mitoxantrone HCl
(CAS: 70476-82-3)

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.

CAS 123948-87-8 Topotecan

Topotecan
(CAS: 123948-87-8)

Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions. ...

Elomotecan HCl salt
(CAS: 220997-99-9)

Elomotecan, also referred to BN 80927 and R 1559, characterized by a stable seven-membered beta-hydroxylactone ring, is a DNA topoisomerase inhibitor. In vivo e...

CAS 169869-90-3 Exatecan mesylate

Exatecan mesylate
(CAS: 169869-90-3)

Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity...

CAS 175519-16-1 Voreloxin Hydrochloride

Voreloxin Hydrochloride
(CAS: 175519-16-1)

Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result...

NSC 660028
(CAS: 153230-81-0)

NSC 660028, an arylamino etoposide analogue, has been found to be a DNA topoisomerase II inhibitor that was once studied due to its potential anticancer activit...

CAS 65271-80-9 Mitoxantrone

Mitoxantrone
(CAS: 65271-80-9)

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is used in the treatment of certai...

CAS 446-72-0 Genistein

Genistein
(CAS: 446-72-0)

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by ...

CAS 867063-97-6 Atiratecan

Atiratecan
(CAS: 867063-97-6)

Atiratecan is a topoisomerase inhibitor. It has potential anticancer activity.

CAS 33419-42-0 Etoposide

Etoposide
(CAS: 33419-42-0)

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

CP 117227
(CAS: 154531-78-9)

CP 117227, a dibenzocyclohepten derivative, has been found to be a Type II DNA topoisomerase inhibitor that was once developed in studies of anticancer.

ABT-719 HCl
(CAS: 162763-53-3)

The hydrochloride salt form of ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacteria...

CAS 308246-52-8 LMP744

LMP744
(CAS: 308246-52-8)

LMP744, also known as NSC706744, is a novel indenoisoquinoline topoisomerase I inhibitor.

CAS 78186-34-2 Bisantrene Dihydrochloride

Bisantrene Dihydrochloride
(CAS: 78186-34-2)

Bisantrene Dihydrochloride is the hydrochloride salt of Bisantrene. Bisantrene, also referred to CL-216942, Cyabin or NSC-337766, an anthracene bishydrazone der...

CAS 169869-90-3 Exatecan Mesylate

Exatecan Mesylate
(CAS: 169869-90-3)

Exatecan Mesylate (DX-8951) is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous sol...

CAS 56390-09-1 Epirubicin Hydrochloride

Epirubicin Hydrochloride
(CAS: 56390-09-1)

Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.

CAS 72496-41-4 Pirarubicin

Pirarubicin
(CAS: 72496-41-4)

Pirarubicin is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an ant...

CAS 213819-48-8 Belotecan hydrochloride

Belotecan hydrochloride
(CAS: 213819-48-8)

Belotecan hydrochloride, also called as CKD-602 hydrochloride, a Topoisomerase I inhibitor, is the hydrochloride salt of the semi-synthetic and water-soluble ca...

Chemical Structure

CAS 74550-97-3 Bimolane

Quick Inquiry

Verification code

Featured Items