Bifonazole - CAS 60628-96-8
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Not Intended for Therapeutic Use. For research use only.
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Bifonazole is an imidazole antifungal drug. Bifonazole is marketed by Bayer under the trade mark Canespor in ointment form.
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1.Thiazole-Based Thiazolidinones as Potent Antimicrobial Agents. Design, Synthesis and Biological Evaluation.
Haroun M1, Tratrat C, Tsolaki E, Geronikaki A2. Comb Chem High Throughput Screen. 2016;19(1):51-7.
As a part of our ongoing project on the design and synthesis of new thiazole derivatives with antimicrobial activity, fourteen new ethyl 2-(2-((E)-((Z)-5-(4-benzyliden)- 4-oxothiazolidin-2-yliden)amino-4-yl)acetates, carrying halogens, methoxy and other groups were synthesized. Compounds were tested against eight Gram positive and negative bacteria as well as eight yeasts and mold by microdilution assay. All compounds showed good activity against all bacteria tested with MIC ranging between 2.3-39.8 µmol/ml x 10(-2) and MBC of 9.2-79.6 µmol/ml x 10(-2). As reference drugs Ampicillin (MIC 24.8-74.4 and MBC 37.2-124.0 µmol/ml x 10(-2)) and Streptomycin (MIC 4,3-17.2 and MBC 8.6-51.6 µmol/ml x 10(-2)) were used. The best activity was observed for 4-bromo derivative. All tested compounds showed excellent antifungal activity against all fungi tested with MIC in the range between 0.3-38.6 µmol/ml x 10(-2) and MFC range of 0.6-77.2 µmol/ml x 10(-2), better than that of reference drugs, Ketoconazole (MIC 38.
2.Antimicrobial activity of the pygidial gland secretion of three ground beetle species (Insecta: Coleoptera: Carabidae).
Nenadić M1, Soković M2, Glamočlija J2, Ćirić A2, Perić-Mataruga V2, Ilijin L2, Tešević V3, Vujisić L3, Todosijević M3, Vesović N1, Ćurčić S4. Naturwissenschaften. 2016 Apr;103(3-4):34. doi: 10.1007/s00114-016-1358-z. Epub 2016 Mar 21.
The antimicrobial properties of the pygidial gland secretions released by the adults of the three ground beetle species, Carabus ullrichii, C. coriaceus, and Abax parallelepipedus, have been tested. Microdilution method was applied for detection of minimal inhibitory concentrations (MICs), minimal bactericidal concentrations (MBCs), and minimal fungicidal concentrations (MFCs). Additionally, morpho-histology of the pygidial glands is investigated. We have tested 16 laboratory and clinical strains of human pathogens-eight bacterial both gram-positive and gram-negative species and eight fungal species. The pygidial secretion samples of C. ullrichii have showed the strongest antimicrobial effect against all strains of treated bacteria and fungi. Staphylococcus aureus, Lysteria monocytogenes, and Salmonella typhimurium proved to be the most sensitive bacterial strains. Penicillium funiculosum proved to be the most sensitive micromycete, while P.
3.[In vitro antifungal susceptibility profile of Scopulariopsis brevicaulis isolated from onychomycosis].
Carrillo-Muñoz AJ1, Tur-Tur C, Cárdenes D, Rojas F, Giusiano G. Rev Esp Quimioter. 2015 Aug;28(4):210-3.
We studied the in vitro antifungal activity profile of amorolfine (AMR), bifonazole (BFZ), clotrimazole (CLZ), econazole (ECZ), fluconazole (FNZ), itraconazole (ITZ), ketoconazole (KTZ), miconazole (MNZ), oxiconazole (OXZ), tioconazole (TCZ) and terbinafine (TRB) against 26 clinical isolates of Scopulariopsis brevicaulis from patients with onychomycosis by means of an standardized microdilution method. Although this opportunistic filamentous fungi was reported as resistant to several broad-spectrum antifungals agents, obtained data shows a better fungistatic in vitro activity of AMR, OXZ and TRB (0.08, 0.3, and 0.35 mg/L, respectively) in comparison to that of CLZ (0.47 mg/L), ECZ (1.48 mg/L), MNZ (1.56 mg/L, BFZ (2.8 mg/L), TCZ (3.33 mg/L), KTZ (3.73 mg/L). FNZ (178.47 mg/L) and ITZ (4.7 mg/L) showed a reduced in vitro antifungal activity against S. brevicaulis. Obtained MICs show the low in vitro antifungal susceptibility of S. brevicaulis to topical drugs for onychomycosis management, with exceptions (AMR, OZX and TRB).
4.Antimicrobial activity of the pygidial gland secretion of the troglophilic ground beetle Laemostenus (Pristonychus) punctatus (Dejean, 1828) (Insecta: Coleoptera: Carabidae).
Nenadić M1, Soković M2, Glamočlija J2, Ćirić A2, Perić-Mataruga V2, Tešević V3, Vujisić L3, Todosijević M3, Vesović N1, Ćurčić S1. Bull Entomol Res. 2016 Mar 28:1-7. [Epub ahead of print]
The antimicrobial activity of the pygidial gland secretion released by adult individuals of the troglophilic ground beetle Laemostenus (Pristonychus) punctatus (Dejean, 1828), applying microdilution method with the aim to detect minimal inhibitory concentration, minimal bactericidal concentration and minimal fungicidal concentration, has been investigated. In addition, morphology of the pygidial glands is observed. We have tested 16 laboratory and clinical strains of human pathogens - eight bacterial both gram-positive and gram-negative species and eight fungal species. The pygidial secretion samples have showed antimicrobial properties against all strains of treated bacteria and fungi. Micrococcus flavus proved to be more resistant compared with other bacterial strains. More significant antimicrobial properties of the secretion are observed against Escherichia coli, which proved to be the most sensitive bacteria. Aspergillus fumigatus proved to be the most resistant, while Penicillium ochrochloron and Penicillium verrucosum var.
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CAS 60628-96-8 Bifonazole

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