Bicyclol - CAS 118159-48-1
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Not Intended for Therapeutic Use. For research use only.
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Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C.
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1.Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats.
Zhen YZ1, Li NR1, He HW1, Zhao SS1, Zhang GL1, Hao XF1, Shao RG1. World J Gastroenterol. 2015 Jun 21;21(23):7155-64. doi: 10.3748/wjg.v21.i23.7155.
AIM: To evaluate the protective effect of bicyclol against bile duct ligation (BDL)-induced hepatic fibrosis in rats.
2.[Bicyclol combined with ganciclovir for treatment of infantile cytomegalovirus hepatitis].
Liu YH1, Jia MY, Liang GJ, Guan HS, Yan AP. Nan Fang Yi Ke Da Xue Xue Bao. 2015 Oct;35(10):1505-7.
OBJECTIVE: To evaluate the therapeutic effects of bicyclol combined with ganciclocir on infantile cytomegalovirus hepatitis.
3.Role of bicyclol in preventing drug-induced liver injury in tuberculosis patients with liver disease.
Chu NH1, Li L2, Zhang X3, Gu J4, Du YD1, Cai C1, Xiao HP4. Int J Tuberc Lung Dis. 2015 Apr;19(4):475-80. doi: 10.5588/ijtld.14.0579.
SETTING: Four hospitals in China.
4.Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice.
Yao XM1, Li Y2, Li HW1, Cheng XY2, Lin AB1, Qu JG1. Can J Physiol Pharmacol. 2016 Jan;94(1):1-8. doi: 10.1139/cjpp-2015-0074. Epub 2015 Sep 22.
Endoplasmic reticulum (ER) stress is known to be involved in the development of several metabolic disorders, including non-alcoholic fatty liver disease (NAFLD). Tetracycline can cause hepatic steatosis, and ER stress may be involved in tetracycline-induced fatty liver. Our previous study showed that bicyclol has been proven to protect against tetracycline-induced fatty liver in mice, and ER stress may also be involved in bicyclol's hepatoprotective effect. Therefore, this study was performed to investigate the underlying mechanisms associated with ER stress and apoptosis, by which bicyclol attenuated tetracycline-induced fatty liver in mice. Bicyclol (300 mg/kg) was given to mice by gavage 3 times. Tetracycline (200 mg/kg, intraperitoneally) was injected at 1 h after the last dose of bicyclol. At 6 h and 24 h after single dose of tetracycline injection, serum ALT, AST, TG, CHO and hepatic histopathological examinations were performed to evaluate liver injuries.
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CAS 118159-48-1 Bicyclol

(CAS: 118159-48-1)

Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C.

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CAS 118159-48-1 Bicyclol

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