|Description||BIBU 1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM) with ~ 100-fold lower potency than ErbB2 (IC50 = 290 nM) and selectivity over a range of other related tyrosine kinases (IC50 > 10 μM). BIBU 1361 blocks downstream EGFR signaling events such as MAPKK/MAPK activation.|
|Brife Description||EGFR tyrosine kinase inhibitor|
|Purity||≥97% by HPLC|
|Synonyms||BIBU 1361 dihydrochloride; BIBU1361 dihydrochloride; BIBU-1361 dihydrochloride; N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride|
JNJ 28871063 hydrochloride
The hydrochloride salt form of JNJ 28871063, which has been found to be a nonquinazoline Pan-ErbB kinase inhibitor and probably could restrain the growth of hum...
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