BI605906 - CAS 960293-88-3
Catalog number:
960293-88-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H22F2N4O3S2
Molecular Weight:
432.51
COA:
Inquire
Targets:
IKK
Description:
BI605906 is a novel pharmacological inhibitors of the IKK family. It inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP in vitro. It also inhibits TNFα-dependent IκB degradation and expression of pro-inflammatory mediators IL-6, IL-1b, and CXCL1/2. It not only prevents the phosphorylation of physiological substrates, but also prevents the phosphorylation of the serine residues in IKKβ that trigger its activation.
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Purity:
>98 %
Appearance:
Solid powder
Synonyms:
BI-605906;3-AMino-4-(1,1-difluoropropyl)-6-(4-Methylsulfonylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxaMide
Solubility:
DMSO: ≥ 33 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
BI605906 not only prevents the phosphorylation of physiological substrates, but also prevents the phosphorylation of the serine residues in IKKβ that trigger its activation.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Boiling Point:
713.7±60.0 °C | Condition: Press: 760 Torr
Density:
1.48±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
IYHHRZBKXXKDDY-UHFFFAOYSA-N
InChI:
InChI=1S/C17H22F2N4O3S2/c1-3-17(18,19)10-8-11(23-6-4-9(5-7-23)28(2,25)26)22-16-12(10)13(20)14(27-16)15(21)24/h8-9H,3-7,20H2,1-2H3,(H2,21,24)
Canonical SMILES:
CCC(C1=CC(=NC2=C1C(=C(S2)C(=O)N)N)N3CCC(CC3)S(=O)(=O)C)(F)F
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CAS 960293-88-3 BI605906

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