|Description||BI605906 is a novel pharmacological inhibitors of the IKK family. It inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP in vitro. It also inhibits TNFα-dependent IκB degradation and expression of pro-inflammatory mediators IL-6, IL-1b, and CXCL1/2. It not only prevents the phosphorylation of physiological substrates, but also prevents the phosphorylation of the serine residues in IKKβ that trigger its activation.|
|Solubility||DMSO: ≥ 33 mg/mL|
|Application||BI605906 not only prevents the phosphorylation of physiological substrates, but also prevents the phosphorylation of the serine residues in IKKβ that trigger its activation.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Boiling Point||713.7±60.0 °C | Condition: Press: 760 Torr|
|Density||1.48±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or...
BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis.
BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
IKK-2 inhibitor VIII
IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor.
PS-1145 is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells.
MLN120B is a potent and effective IKKbeta inhibitor. It is currently being explored for treatment of inflammatory diseases such as COPD and asthma.
Amlexanox is a specific inhibitor of IKKε and TBK1, which inhibits IKKε and TBK1 activity as determined by MBP phosphorylation.
BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1. It exhibits no effect against a panel of 15 other kinases and attenuate...
LY2409881 is a novel selective inhibitor of IKK2. It inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition an...
Bay 65-1942 hydrochloride
Bay 65-1942 hydrochloride is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κβ pathway.
IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase and is inactive at IKK-α and IKK-β.
IKK16 is a selective IκB kinase (IKK) inhibitor for IKK-2( IC50=40 nM), IKK complex( IC50=70 nM) and IKK-1(IC50=2000 nM).
Bay 65-1942 R form
Bay 65-1942 R form is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
BI605906 is a novel pharmacological inhibitors of the IKK family. It inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP in vitro. It also inh...
LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
Bay 65-1942 free base
Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38...
AZD3264 is a novel IKK2 inhibitor.