BI-847325 - CAS 1207293-36-4
Catalog number: B0084-470824
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H28N4O2
Molecular Weight:
464.56
COA:
Inquire
Targets:
Aurora Kinase | MEK
Description:
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-470824 10 mg $169 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Solid Powder
Synonyms:
BI 847325; BI847325
Solubility:
DMSO: 19mg/mL warmed(40.89mM); Ethanol: 1mg/mL(2.15mM); Water: <1mg/mL(<1mM)
Storage:
3 years -20℃ powder; 6 months -80℃ in solvent
MSDS:
Inquire
Shelf Life:
2 years
InChIKey:
FLBNLJLONKAPLR-DQSJHHFOSA-N
InChI:
InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8-6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2,1-3H3,(H,30,34)(H,32,35)/b28-27-
Canonical SMILES:
CCNC(=O)C#CC1=CC2=C(C=C1)C(=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN(C)C)C(=O)N2
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Aurora Kinase Products


BI-847325
(CAS: 1207293-36-4)

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B...

CAS 1158838-43-7 Aurora A inhibitor II

Aurora A inhibitor II
(CAS: 1158838-43-7)

Aurora A inhibitor II is a potent and selective inhibitor of Aurora A kinase (AurA; IC50 = 4.3 nM).

CAS 693228-63-6 CYC116

CYC116
(CAS: 693228-63-6)

CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active ...

CAS 934660-94-3 Cobimetinib (R-enantiomer)

Cobimetinib (R-enantiomer)
(CAS: 934660-94-3)

Cobimetinib (R-enantiomer) is a selective inhibitor of MEK. It is also known as mitogen activated protein kinase kinase (MAPKK) and is a key component of the RA...

CAS 722543-31-9 Barasertib

Barasertib
(CAS: 722543-31-9)

Barasertib is an orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152–hydroxyquinazolin...

Cobimetinib hemifumarate
(CAS: 1369665-02-0)

Cobimetinib, also known as GDC-0973 and XL-518, is a novel selective MEK inhibitor, and the IC50value against MEK1 is 4.2 nM, with potential antineoplastic acti...

CAS 1245907-03-2 TC-A 2317 hydrochloride

TC-A 2317 hydrochloride
(CAS: 1245907-03-2)

TC-A 2317 hydrochloride is a selective and potent Aurora kinase A (ARK-1) inhibitor (Ki = 1.2 nM and 101 nM for inhibition of Aurora kinase A and Aurora kinase ...

CAS 934660-93-2 Cobimetinib

Cobimetinib
(CAS: 934660-93-2)

cobimetinib, also known as GDC-0973 and XL-518, is an orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1)...

CAS 422513-13-1 Hesperadin

Hesperadin
(CAS: 422513-13-1)

Hesperadin is  an inhibitor of human Aurora B, which can prevent the phosphorylation of substrate with IC(50) of 40 nM. Growth of cultured bloodstream forms was...

CAS 874101-00-5 RO4987655

RO4987655
(CAS: 874101-00-5)

RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK ...

CAS 391210-10-9 PD-0325901

PD-0325901
(CAS: 391210-10-9)

PD-0325901 i a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential an...

CAS 896466-04-9 AT9283

AT9283
(CAS: 896466-04-9)

AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50= 3, 3, 1.2, 1.1, and 4 nM, respectively). It...

CAS 1035555-63-5 TAK-733

TAK-733
(CAS: 1035555-63-5)

TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor TAK-733 selectively b...

CAS 1094069-99-4 SCH-1473759

SCH-1473759
(CAS: 1094069-99-4)

SCH-1473759 is a novel sub-nanomolar Aurora A/B inhibitor. SCH 1473759 was active against a large panel of tumor cell lines from different tissue origin and gen...

CAS 108923-79-1 U0124

U0124
(CAS: 108923-79-1)

U0124 is an inactive analog of U0126 that can be used as a negative control. U0124 has no inhibitory effects on MEK at concentrations up to 100 μM.

CAS 934541-31-8 TAK-901

TAK-901
(CAS: 934541-31-8)

TAK-901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK-901 binds to...

CAS 1010085-13-8 MK-5198

MK-5198
(CAS: 1010085-13-8)

MK-5108 is a novel small molecule with potent inhibitory activity against Aurora-A kinase. Although most of the Aurora-kinase inhibitors target both Aurora-A an...

CAS 942918-07-2 GSK-1070916A

GSK-1070916A
(CAS: 942918-07-2)

GSK-1070916A is an ATP-competitive inhibitor of the serine/threonine kinases Aurora B and C with potential antineoplastic activity. Aurora B/C kinase inhibitor ...

CAS 871700-17-3 Trametinib

Trametinib
(CAS: 871700-17-3)

Trametinib is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM and no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.

CAS 1291074-87-7 ENMD-2076 L-(+)-Tartaric acid

ENMD-2076 L-(+)-Tartaric acid
(CAS: 1291074-87-7)

ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more selec...

Quick Inquiry

Verification code

Featured Items