BI-7273 - CAS 1883429-21-7
Catalog number: 1883429-21-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H23N3O3
Molecular Weight:
353.422
COA:
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Targets:
BRD9
Description:
BI-7273 is a potent BRD9 bromodomain inhibitor (Ki = 15.4 nM; IC50 = 19 nM).BI-7273 structurally related BRD7 bromodomain (IC50 = 117 nM)without effect against the BRD2 and BRD4 bromodomain or a panel of kinases. BI-7273 has potential for use in treating acute myeloid leukemia according to a study in vitro (EC50 = 1.4 µM).
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Brife Description:
BRD9 bromodomain inhibitor,BRD9,leukemia
Purity:
>98%
Appearance:
solid powder
Synonyms:
4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1-one; GTPL9146; CHEMBL3823478; EX-A990; AKOS030528616; ZINC575448880
Solubility:
Soluble in DMSO.
Storage:
Store in a cool and dry place and at0-4℃ for short term(days to weeks)or -66℃ for long term(months to years).
MSDS:
Inquire
Application:
A potent BRD9 bromodomain inhibitor for the treatment of leukemia.
Shelf Life:
2 years
Boiling Point:
528.1±50.0 °C at 760 mmHg
Density:
1.2±0.1 g/cm3
InChIKey:
RBUYFHLQNPJMQM-UHFFFAOYSA-N
InChI:
InChI=1S/C20H23N3O3/c1-22(2)11-17-18(25-4)8-13(9-19(17)26-5)16-12-23(3)20(24)15-10-21-7-6-14(15)16/h6-10,12H,11H2,1-5H3
Canonical SMILES:
CN1C=C(C2=C(C1=O)C=NC=C2)C3=CC(=C(C(=C3)OC)CN(C)C)OC
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