Bethanechol Chloride - CAS 590-63-6
Catalog number: 590-63-6
Category: Inhibitor
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A selective muscarinic receptor stimulant, used to treat cerebral palsy.
white to off-white solid
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1.[Medical treatment of disorders of the bladder sphincter].
Dagues F;Costa P Rev Prat. 1995 Feb 1;45(3):337-41.
A lot of drugs can increase or decrease bladder activity or urethral sphincter activity. Some of them are used for treatment of incontinence or chronic retention. In case of severe pollakiuria or urge incontinence secondary to bladder instability, numerous medications can be used: anticholinergic agents, musculotropic relaxants, calcium antagonists, prostaglandin inhibitors, beta-adrenergic agonists, tricyclic antidepressants. Anticholinergic agents are regularly used on first choice. When stress incontinence is present, alpha agonists administered with estrogen and perineal reeducation represent the first stage before surgery. For medical treatment of retention, if there is not outlet obstruction, one can increase detrusor activity with betanechol chloride. In case of outlet obstruction, alpha-blockers or 5 alpha-reductase inhibitors can be used, if there is benign prostatic hyperplasia. Pygeum africanum can be used, but to date there is no clinical study proving its efficacy.
2.Biochemical reactions involved in pancreatic enzyme secretion. 4. Effects of cytochalasin B on functions of the exocrine pancreas.
Morisset J;Beaudoin AR Can J Physiol Pharmacol. 1977 Jun;55(3):644-51.
These experiments were performed to evaluate the effects of cytochalasin B on pancreatic enzyme secretion and thus perhaps establish a role for microfilaments in the exocytosis process. The alkaloid at a concentration of 1 microgram/ml (2micron) inhibits amylase secretion induced by urecholine or cholecystokinin-pancreozymin (CCK-PZ) but does not modify that induced by dibutyryl cyclic AMP. The inhibitory effect of the drug is reversible after a 30-min washing out period. It does not affect O2 consumption, basal calcium efflux, or efflux caused by CCK-PZ. Amino acid accumulation in the tissue and their incorporation into proteins are not modified. It is suggested that cytochalasin B inhibits pancreatic enzyme secretion, probably through an effect on the microfilament system.
3.[Diurnal enuresis in childhood is effectively treated with terodiline].
Elmér M;Adolfsson T;Nørgaard JP;Djurhuus JC Lakartidningen. 1991 Mar 6;88(10):850-1.
Efficacy and tolerance of the anticholinergic calcium antagonist, terodiline (Mictrol), were investigated in a placebo-controlled double-blind cross-over study of 42 children with diurnal enuresis. At a daily dosage of 25 mg, terodiline was well tolerated and, as compared with placebo, resulted in a statistically significant reduction in the daily frequency of wetting. Thus the findings show terodiline to be effective in the treatment of diurnal enuresis, an added advantage being the low incidence of side effects. A full report in English is given in Scand J Prim Health Care 1988; 6:119-24.
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CAS 590-63-6 Bethanechol Chloride

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