Betaxolol HCl - CAS 63659-19-8
Catalog number:
63659-19-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H29NO3·HCl
Molecular Weight:
343.89
COA:
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Targets:
Adrenergic Receptor
Description:
Betaxolol is a β1 adrenergic receptor blocker with IC50 of 6 μM.
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Purity:
>98%
Synonyms:
BAY K 5552
MSDS:
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1.[Preservative-free betaxolol for POAG patients: evaluation of hypotensive effect and ocular surface safety].
Onischenko AL, Dimaksyan MV, Kolbasko AV, Zilina NM. Vestn Oftalmol. 2015 Mar-Apr;131(2):76-80.
AIM: To evaluate ocular surface changes in patients with primary open-angle glaucoma (POAG) as well as the hypotensive effect of preservative-free betaxolol eye drops.
2.On-line coupling of Micro-Extraction by Packed Sorbent with Sequential Injection Chromatography system for direct extraction and determination of betaxolol in human urine.
Šrámková I1, Chocholouš P1, Sklenářová H1, Šatínský D2. Talanta. 2015 Oct 1;143:132-7. doi: 10.1016/j.talanta.2015.05.048. Epub 2015 May 22.
A novel approach for automation of Micro-Extraction by Packed Sorbent (MEPS), a solid phase extraction technique, is presented, enabling precise and repeatable liquid handling due to the employment of sequential injection technique. The developed system was used for human urine sample clean-up and pre-concentration of betaxolol before its separation and determination. A commercial MEPS C-18 cartridge was integrated into an SIChrom™ system. The chromatographic separation was performed on a monolithic High Resolution C18 (50×4.6 mm) column which was coupled on-line in the system with Micro-Extraction using an additional selection valve. A mixture of acetonitrile and aqueous solution of 0.5% triethylamine with acetic acid, pH adjusted to 4.5 in ratio 30:70 was used as a mobile phase for elution of betaxolol from MEPS directly onto the monolithic column where the separation took place. Betaxolol was quantified by a fluorescence detector at wavelengths λ(ex)=220 nm and λ(em)=305 nm.
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CAS 63659-19-8 Betaxolol HCl

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