Betamethasone - CAS 378-44-9
Catalog number: B0084-091355
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C22H29FO5
Molecular Weight:
392.46
COA:
Certificate of Analysis-Betamethasone 378-44-9 B15L0908  
Targets:
Glucocorticoid Receptor
Description:
Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments, including allergic reactions to poison ivy and similar plants.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-091355 10 g $199 In stock
Bulk Inquiry
Purity:
99%
Appearance:
White powder
Synonyms:
9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16β-methylprednisolone
MSDS:
Inquire
Application:
API
Quality Standard:
EP
Quantity:
Grams-Kilos
InChIKey:
UREBDLICKHMUKA-DVTGEIKXSA-N
InChI:
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
Canonical SMILES:
CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
1. Evaluation of electrospun fibers as solid phase extraction sorbents for sample preparation in HPLC-MS/MS confirmatory doping control analysis of dexamethasone and betamethasone
Tania Possi-Pezzali, Samuel Chigome, Alejandra Rodr´ ıguez-Haralambides*, Nelson Torto. Anal. Methods, 2013, 5, 4230–4237
Polystyrene fibers were fabricated by electrospinning and evaluated their capacity to interact with twomodel drugs for sample preparation. The packing in microcolumn devices showed high recoveries for dexamethasone and betamethasone in water and urine samples, and breakthrough volumes measured for both analytes indicated that the system could be applicable not only for a clean-up but also as a pre-concentration step. This sample preparation approach was successfully applied to urine samples to detect the presence of dexamethasone and betamethasone by HPLC-MS/MS for qualitative confirmatory analyses. The method requires only 200 mL of methanol per sample, and the extraction is performed in less than 15 min.
2. The conversion of allenes to strained three-membered heterocycles
C. S. Adams, C. D. Weatherly, E. G. Burke and J. M. Schomaker*. Chem. Soc. Rev., 2014, 43, 3136—3163
In 1996, chemists at Schering-Plough reported an alternative approach to the corticoid betamethasone that proceeded through an SDE intermediate. Treatment of the steroidal allene with in situ-generated DMDO provided the requisite SDE in 2 : 1 dr; however, ring-opening with Bu4NOAc provided a single ketone product, indicating that the source of diastereoselectivity was at C20. The disubstituted ketone was obtained in 85% over two steps, and was readily carried on to a known betamethasone precursor.
3. Quantitative determination of betamethasone sodium phosphate and betamethasone dipropionate in human plasma by UPLC-MS/MS and a bioequivalence study
Man-Yun Chen, Yong-Jun Tang, Zhi-Rong Tan,* Wei-Hua Huang*. Anal. Methods,2016, 8, 3550–3563
BSP and BDP could be hydrolyzed by phosphatase as fast-release phosphate prodrugs and esterase enzymes as sustained-release dipropionate prodrugs into active pharmaceutical ingredients betamethasone (BOH), betamethasone 17-monodipropionate (B17P) and betamethasone 21-monodipropionate (B21P), respectively. Because the activating enzymes such as phosphate and esterase were highly efficient and ubiquitous in human blood, BSP that was highly ionized and hydrophilic could be rapidly absorbed into blood from the administration place and then be metabolized quickly into active betamethasone (BOH) without a rate-limiting step.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Glucocorticoid Receptor Products


CAS 50-23-7 Hydrocortisone

Hydrocortisone
(CAS: 50-23-7)

Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.

1,1,1-trifluoro-3-(5-fluoro-2-methoxy-ph

A glucocorticoid receptor modulator.

CAS 669073-68-1 (+)-ZK 216348

(+)-ZK 216348
(CAS: 669073-68-1)

(+)-ZK 216348 is a selective nonsteroidal glucocorticoid receptor (GR) agonist for the treatment of experimental colitis (IC50 values of 20, 20, and 80 nM for G...

CAS 76-25-5 Triamcinolone Acetonide

Triamcinolone Acetonide
(CAS: 76-25-5)

Triamcinolone Acetonide is a long-acting synthetic and a more potent type of triamcinolone, about 8 times as effective as prednisone.

CAS 1196509-60-0 AZD-7594

AZD-7594
(CAS: 1196509-60-0)

AZD-7594 is an inhaled selective glucocorticoid receptor (GCCR) modulator.

CAS 124-94-7 Triamcinolone

Triamcinolone
(CAS: 124-94-7)

Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topic...

CAS 638-94-8 Desonide

Desonide
(CAS: 638-94-8)

Desonide is the generic name of a low potency topical corticosteroid that has been available since the 1970s. It is primarily used to treat atopic dermatitis (e...

CAS 956901-32-9 Betamethasone hydrochloride

Betamethasone hydrochloride
(CAS: 956901-32-9)

Betamethasone hydrochloride is the hydrochloride of betamethasone, which is a synthetic corticosteroid and agonist of glucocorticoid receptor. It does not cause...

Chemical Structure

CAS 378-44-9 Betamethasone

Quick Inquiry

Verification code

Featured Items