Betahistine - CAS 5638-76-6
Catalog number:
5638-76-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C8H12N2
Molecular Weight:
136.20
COA:
Inquire
Targets:
Histamine Receptor
Description:
Betahistine is a H1 receptor agonist, which serves as a vasodilator. It is used in Meniere disease and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. It is an antivertigo drug first used for treating vertigo. It is also commonly used for patients with balance disorders. It is believed to act by reducing the asymmetrical functioning of sensory vestibular organs as well as by increasing vestibulocochlear blood flow. It also acts as a histamine H3-receptor antagonist which causes an increased output of histamine from histaminergic nerve endings which can further increase the direct H1-agonist activity. It has been listed.
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Purity:
98%
Appearance:
Colourless liquid
Synonyms:
BRN0112294;BRN-0112294;beta-Histine;N-methyl-2-(pyridin-2-yl)ethan-1-amine;Pyridine,2-[2-(methylamino)ethyl]- (6CI,7CI,8CI);2-(2-Methylaminoethyl)pyridine;Methyl(2-pyridin-2-ylethyl)amine;N-Methyl-2-(2-pyridinyl)ethanamine;N-Methyl-N-[2-(2-pyridinyl)ethyl
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Betahistine is used in Meniere disease and in vascular headaches. It is an antivertigo drug first used for treating vertigo. It is also commonly used for patients with balance disorders.
Quality Standard:
In-house standard
Quantity:
Grams to Kilograms
Boiling Point:
113-114 °C
Melting Point:
148-149℃
Density:
0.984 g/cm3
InChIKey:
UUQMNUMQCIQDMZ-UHFFFAOYSA-N
InChI:
InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3
Canonical SMILES:
CNCCC1=CC=CC=N1
Current Developer:
Betahistine has been listed.
1.Thioether sulfur oxygenation from O2 or H2O2 reactivity of copper complexes with tridentate N2Sthioether ligands.
Lee Y1, Lee DH, Sarjeant AA, Zakharov LN, Rheingold AL, Karlin KD. Inorg Chem. 2006 Dec 11;45(25):10098-107.
To model thioether-copper coordination chemistry including oxidative reactivity, such as occurs in the copper monooxygenases peptidylglycine -hydroxylating monooxygenase (PHM) and dopamine beta-hydroxylase (DbetaH), we have synthesized new tridentate N2S ligands LSEP and LSBz [LSEP = methyl(2-phenethylsulfanylpropyl)(2-pyridin-2-ylethyl)amine; LSBz = (2-benzylsulfanylpropyl)methyl(2-pyridin-2-ylethyl)amine)]. Both copper(I) and copper(II) complexes have been prepared, and their respective O2 and H2O2 chemistry has been studied. Under mild conditions, oxygenation of [(LSEP)CuI]+ (1a) and [(LSBz)CuI]+ (2a) leads to ligand sulfoxidation, thus exhibiting copper monooxygenase activity. A copper(II) complex of this sulfoxide ligand product, [(LSOEP)CuII(CH3OH)(OClO3)2], has been structurally characterized, demonstrating Cu-Osulfoxide ligation. The X-ray structure of [(LSEP)CuII(H2O)(OClO3)]+ (1b) and its solution UV-visible spectral properties [S-CuII LMCT band at 365 nm (MeCN solvent); epsilon = 4285 M-1 cm-1] indicate the thioether sulfur atom is bound to the cupric ion in both the solid (CuII-S distance: 2.
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CAS 5638-76-6 Betahistine

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