(beta)-Estradiol 17-acetate - CAS 1743-60-8
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
β-Estradiol 17-acetate is a metabolite of estradiol.
Publictions citing BOC Sciences Products
  • >> More
1,3,5(10)-Estratriene-3,17β-diol 17-acetate
1.LCAT facilitates transacylation of 17 beta-estradiol in the presence of HDL3 subfraction.
Höckerstedt A1, Tikkanen MJ, Jauhiainen M. J Lipid Res. 2002 Mar;43(3):392-7.
It has been shown that estrogens need to be metabolized to their hydrophobic estrogen ester derivatives to act as antioxidants in lipoproteins. Data suggest that 17beta-estradiol (E(2)) becomes esterified in LCAT-induced reactions and the esters are transported from HDL particles to LDL and VLDL particles by a CETP-dependent mechanism. In the present study we have further investigated the regulation of E(2) esterification by LCAT and focused on the importance of HDL structure and composition in the esterification process. Isolated LDL, HDL(2), HDL(3), and reconstituted discoidal HDL (rHDL) were incubated with labeled E(2), with and without purified LCAT, at 37 degrees C for 24 h. After purification of the lipoprotein fractions, there was a significant peak of radioactivity representing esterified estradiol attached to HDL(3) and rHDL, but HDL(2) and LDL contained only trace amounts of labeled estradiol ester. TLC analysis confirmed that the radioactivity migrated in a position corresponding to that of 17beta-E(2) 17-monoester standard.
2.The influence of 17-beta-estradiol 17-beta-acetate on adenylyl cyclase activity and aminoacyl-tRNA synthetase phosphatase activity in ovariectomized NMRI mice.
Berg BH1. Biochem Int. 1991 Jun;24(3):527-33.
Adenylyl cyclase activity in the uterus of ovariectomized NMRI mice showed an increase of 87% four minutes after intraperitoneal administration of 17-beta-estradiol 17-beta-acetate in water solution, while in the liver of the same animals activity had decreased by 57%. At the same time, the activity of the 51 kDa form of the aminoacyl-tRNA synthetase phosphatase in the uterus showed an increase of 400%, while in the liver a decrease of 60% was observed. Sixty minutes after hormone injection the adenylyl cyclase activities showed no difference from controls.
3.Reversal of the effect of 17-beta-estradiol 17-beta-acetate on aminoacyl-tRNA synthetase phosphatase and aminoacyl-tRNA synthetase activities in the uterus and liver of ovariectomized Bom:NMRI mice by 2-deoxyadenosine 3-phosphate.
Berg BH1. Biochem Mol Biol Int. 1993 Apr;29(5):959-64.
When an adenylyl cyclase inhibitor, 2-deoxyadenosine 3'-phosphate, was administered together with 17-beta-estradiol 17-beta-acetate on ovariectomized Bom:NMRI mice, the short term effects of the hormone on the uterus aminoacyl-tRNA synthetase phosphatase and aminoacyl-tRNA synthetase activities were reversed, whereas the effect on the liver enzymes was about the same for 17-beta-estradiol 17-beta-acetate and for 2-deoxyadenosine 3-phosphate.
4.Synthesis and properties of benzo [d,e]estra-1,3,5(10)-triene-3, 17 beta-diol 17-acetate.
Castelli PP, Vitali R, Briziarelli G, Gardi R. Experientia. 1981 Jan 15;37(1):10-1.
A new pentacyclic analogue of estradiol, benzo[d,e]estradiol 17-acetate, has been prepared and investigated for its hormonal and antitumor activity. Unlike related testosterone derivatives, the new compound did not display any interesting property.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

(CAS: 410074-73-6)

Amitifadine is an antidepressant drug candidate which reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (ME...

CAS 39432-56-9 Eleutheroside E

Eleutheroside E
(CAS: 39432-56-9)

Eleutheroside E has anti-inflammatory effect by inhibiting NF-κB activities.

CAS 63238-67-5 Benzoylmesaconine

(CAS: 63238-67-5)

Benzoylmesaconine is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis.

CAS 47931-85-1 Calcitonin salmon

Calcitonin salmon
(CAS: 47931-85-1)

Calcitonin salmon, a calcium regulating hormone, has been shown to be an effective alternative for the treatment of postmenopausal osteoporosis.

(CAS: 105424-59-7)

FR-900490 is a new type of immunoactive substance isolated from Disocia sp. F-11809. It is effective in reversing the damage to bone marrow caused by mitomycin ...

CAS 20537-88-6 Amifostine

(CAS: 20537-88-6)

Amifostine is a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) meta...

CAS 599-79-1 Sulfasalazine

(CAS: 599-79-1)

Sulfasalazine (brand name Azulfidine in the U.S., Salazopyrin and Sulazine in Europe and Hong Kong) was developed in the 1950s specifically to treat rheumatoid ...

CAS 51-48-9 L-Thyroxine

(CAS: 51-48-9)

L-Thyroxine is a synthetic form of thyroxine and a hormone replacement drug.

CI 924
(CAS: 79520-77-7)

CI 924 is hypolipidemic agent. It can elevate anti-atherogenic HDL and lower VLDL.

CAS 60166-93-0 Iopamidol

(CAS: 60166-93-0)

Iopamidol is a nonionic, low-osmolar iodinated contrast agent, developed by Bracco.

CAS 84272-85-5 4-O-beta-D-gulcosyl-5-O-methylvisamminol

(CAS: 84272-85-5)

4-O-β-D-Glucosyl-5-O-methyllvisamminol is a natural product isolated from the roots of Saposhnikovia divaricata (Turcz.) Schischk. It is a novel epigenetic supp...

CAS 23496-41-5 Peimine

(CAS: 23496-41-5)

Anti-inflammatory agent. MAPK inhibitor. Inhibits p38, ERK and JNK phosphorylation. Inhibits NFκB activation. Shows antitussive, expectorant and anti-inflammato...

CAS 4618-18-2 Lactulose

(CAS: 4618-18-2)

Lactulose, a disaccharide composed of galactose and fructose, is a stimulator of health-promoting bacterium growth in the gastrointestinal tract, used to treat ...

CAS 1218942-37-0 GKT137831

(CAS: 1218942-37-0)

GKT137831 attenuates hypoxia-induced H(2)O(2) release, cell proliferation, and TGF-β1 expression and blunted reductions in PPARγ in HPAECs and HPASMCs.

CAS 452-35-7 Ethoxzolamide

(CAS: 452-35-7)

Ethoxzolamide is used in the treatment of glaucoma, and is also used as a diuretic, acting as a carbonic anhydrase inhibitor.

CAS 63550-99-2 Rebaudioside C

Rebaudioside C
(CAS: 63550-99-2)

Rebaudioside C is used as natural sweeteners to diabetics and others on carbohydrate-controlled diets.

CAS 312756-74-4 RS-1

(CAS: 312756-74-4)

RS-1, a cell-permeable sulfonamido-benzamide compound that increases the DNA binding activity of RAD51 (Kd range = 48-107 nM, value depends on cofactors present...

CAS 153381-68-1 7-Epi-docetaxel

(CAS: 153381-68-1)

An isomer of Docetaxel (D494420). Docetaxel injection impurity C.

CAS 31828-71-4 Mexilitine

(CAS: 31828-71-4)

Mexiletine is a non-selective voltage-gated sodium channel blocker used to treat arrhythmias within the heart, or seriously irregular heartbeats.

CAS 33089-61-1 Amitraz

(CAS: 33089-61-1)

Amitraz is a non-systemic acaricide and insecticide, as an antiparasitic used to control red spider mites, leaf miners and scale insects.

Chemical Structure

CAS 1743-60-8 (beta)-Estradiol 17-acetate

Quick Inquiry

Verification code

Featured Items