Bergenin - CAS 477-90-7
Catalog number: 477-90-7
Category: Inhibitor
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Molecular Formula:
C14H16O9
Molecular Weight:
328.27
COA:
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Targets:
Others
Description:
Bergenin is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.It shows a potent immunomodulatory effect.
Purity:
>98%
Synonyms:
Cuscutin
MSDS:
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InChIKey:
YWJXCIXBAKGUKZ-HJJNZUOJSA-N
InChI:
InChI=1S/C14H16O9/c1-21-11-5(16)2-4-7(9(11)18)12-13(23-14(4)20)10(19)8(17)6(3-15)22-12/h2,6,8,10,12-13,15-19H,3H2,1H3/t6-,8-,10+,12+,13-/m1/s1
Canonical SMILES:
COC1=C(C=C2C(=C1O)C3C(C(C(C(O3)CO)O)O)OC2=O)O
1.Bergenin determination in different extracts by high-performance thin-layer chromatographic densitometry.
Khan MS1, Khan W1, Ahmad W1, Singh M1, Ahmad S1. J Pharm Bioallied Sci. 2015 Oct-Dec;7(4):272-4. doi: 10.4103/0975-7406.168024.
AIM: Bergenin is an active secondary metabolite, found in Bergenia ligulata, family Saxifragaceae, which is an important medicinal plant used in the traditional system of medicine. It is distributed throughout the South and East Asia and some European countries, usually growing on high altitude in the Himalayan region and known as Pashanbhed (meaning "to break the stone"). The rhizome of B. ligulata has been used since long time in different traditional formulations of kidney and liver disorders. Due to its exhaustive use in the traditional system, it is commonly adulterated with the rhizome of other plants which do not contain its chemical marker bergenin. Hence, we developed high-performance thin-layer chromatographic (HPTLC) method for quantification of bergenin in B. ligulata which can be used for its quality control.
2.Bergenin determination in different extracts by high-performance thin-layer chromatographic densitometry.
Khan MS1, Khan W1, Ahmad W1, Singh M1, Ahmad S1. J Pharm Bioallied Sci. 2015 Oct-Dec;7(4):272-4. doi: 10.4103/0975-7406.168024.
AIM: Bergenin is an active secondary metabolite, found in Bergenia ligulata, family Saxifragaceae, which is an important medicinal plant used in the traditional system of medicine. It is distributed throughout the South and East Asia and some European countries, usually growing on high altitude in the Himalayan region and known as Pashanbhed (meaning "to break the stone"). The rhizome of B. ligulata has been used since long time in different traditional formulations of kidney and liver disorders. Due to its exhaustive use in the traditional system, it is commonly adulterated with the rhizome of other plants which do not contain its chemical marker bergenin. Hence, we developed high-performance thin-layer chromatographic (HPTLC) method for quantification of bergenin in B. ligulata which can be used for its quality control.
3.Glycoside-based niosomal nanocarrier for enhanced in-vivo performance of Cefixime.
Imran M1, Shah MR2, Ullah F3, Ullah S4, Elhissi AM5, Nawaz W6, Ahmad F7, Sadiq A8, Ali I9. Int J Pharm. 2016 Apr 2;505(1-2):122-132. doi: 10.1016/j.ijpharm.2016.03.042. [Epub ahead of print]
This study aimed to evaluate the potential of a novel glycoside non-ionic surfactant synthesized and characterized in our laboratory for increased oral bioavailability of Cefixime. The surfactant was synthesized by simple etherification of bergenin with bromoundecane and characterized by 1H NMR and mass spectroscopy (MS). Biocompatibility of the surfactant (BRM-BG) was assessed by in-vitro cytotoxicity against NIH/3T3 cells and human blood hemolysis. In-vivo acute toxicity was evaluated in mices. Cefixime loaded BRM-BG niosomes were investigated for drug entrapment efficiency using HPLC and surface morphology and vesicle size by atomic force microscopy (AFM) and dynamic light scattering (DLS). The in-vivo oral bioavailability and pharmacokinetics studies were carried out using rabbits. Cefixime loaded BRM-BG vesicles were spherical in the size range of 178.66±8.17nm with a polydipersity index (PDI) of 0.20±0.01, offering an entrapment efficiency as high as 78.
4.Isolation of bergenin from the root bark of Securinega virosa and evaluation of its potential sleep promoting effect.
Magaji MG1, Musa AM2, Abdullahi MI3, Ya'u J1, Hussaini IM4. Avicenna J Phytomed. 2015 Nov-Dec;5(6):587-96.
OBJECTIVES: Securinega virosa Roxb (Ex Willd) Baill (Euphorbaiceae) root bark has been reportedly used in African traditional medicine in the management of mental illnesses. Previously, the sleep-inducing potential of the crude methanol root bark of Securinega virosa extract and its butanol fraction have been reported. The study aimed to isolate and characterize the bioactive constituent that may be responsible for the sleep inducing property of the root of the plant.
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CAS 477-90-7 Bergenin

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