Berberine hydrochloride - CAS 633-65-8
Catalog number: B0084-073975
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C20H18ClNO4
Molecular Weight:
371.817
COA:
Inquire
Targets:
Cox-2
Description:
Berberine hydrochloride is an isoqinoline alkaloid and acts as a COX-2 inhibitor that exhibits chemopreventive activity against colon tumor formation. Study in humans and hamsters shows that berberine reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides. It also inhibits c-Jun and suppresses inflammation and cancers.
Nutritional supplement in health care products.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-073975 250 g $199 In stock
Bulk Inquiry
Brife Description:
COX-2 inhibitor
Purity:
≥ 98%
Related CAS:
2086-83-1 (free base)
Appearance:
Pale Yellow to Yellow Solid
Synonyms:
Berberine chloride; Natural Yellow 18; Benzodioxide; Berberinium chloride
MSDS:
Inquire
Application:
Ingredient of health care products.
Melting Point:
>160°C (dec.)
InChIKey:
VKJGBAJNNALVAV-UHFFFAOYSA-M
InChI:
InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
Canonical SMILES:
COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
1.Intact noradrenaline transporter is needed for the sympathetic fine-tuning of cytokine balance.
Selmeczy Z1, Szelényi J, Vizi ES. Eur J Pharmacol. 2003 May 23;469(1-3):175-81.
Earlier studies demonstrated that cytokine production is under the tonic control of noradrenaline. As the level and/or the duration of noradrenaline action is regulated by the noradrenaline transporter (NET), which is also a target of antidepressant treatment, we studied its role in the regulation of the cytokine response during inflammation. The endotoxin-evoked tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 response was studied in genetically produced noradrenaline transporter-deficient (NET-KO) mice and by treatment with desipramine, a monoamine uptake-blocker antidepressant. NET-KO mice responded to endotoxin with significantly lower TNF-alpha and interleukin-10 production in comparison to their wild-type counterparts. Functional involvement of both alpha- and beta-adrenoceptors could be demonstrated in our model systems, using 7,8-methylenedioxy-14 alpha-hydroxy-alloberbane.HCl (CH-38083) and propranolol; however, the differences between the two phenotypes remained, suggesting a limited role of alpha-adrenoceptors in the observed changes.
2.Interaction of baicalin with berberine for glucose uptake in 3T3-L1 adipocytes and HepG2 hepatocytes.
Zhang CH1, Yu RY1, Liu YH1, Tu XY1, Tu J2, Wang YS3, Xu GL4. J Ethnopharmacol. 2014 Feb 3;151(2):864-72. doi: 10.1016/j.jep.2013.11.054. Epub 2013 Dec 18.
ETHNOPHARMACOLOGICAL RELEVANCE: Baicalin and berberine are important coexisting constituents of the combination of Radix Scutellariae and Rhizoma Coptidis, known as scutellaria-coptis herb couple (SC), which has heat clearing and detoxifying effects. The aims of the present study were to investigate the effects of the combination of baicalin+berberine on glucose uptake in 3T3-L1 adipocytes or HepG2 cells.
3.[Five alkaloids from vine stems of Diploclisia affinis].
Wang EJ1, Ma YB, Zhang XM, Jiang ZY, Chen JJ. Zhongguo Zhong Yao Za Zhi. 2008 Nov;33(21):2503-5.
OBJECTIVE: To study alkaloid constituents of Diploclisia affinis.
4.Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors.
Vizi ES1, Zsilla G, Caron MG, Kiss JP. J Neurosci. 2004 Sep 8;24(36):7888-94.
Our aim was to investigate the functional properties of the noradrenergic system in genetically modified mice lacking the norepinephrine transporter (NET). We measured the uptake and release of [(3)H]norepinephrine ([(3)H]NE) from hippocampal and cortical slices of NET(-/-) knock-out (KO) and NET(+/+) wild-type (WT) mice and investigated the presynaptic alpha2-adenoceptor-mediated modulation of NE release in vitro and in vivo. The [(3)H]NE uptake was reduced to 12.6% (hippocampus) and 33.5% (frontal cortex) of WT control in KO mice. The neuronal component of this residual uptake was decreased by 79.4 and 100%, respectively, when a selective serotonin reuptake inhibitor (SSRI) citalopram was present during the loading. The more preserved neuronal release of [(3)H]NE (hippocampus, 28.1%; frontal cortex, 74.4%; compared with WT) almost completely disappeared in both regions (94.1 and 95.3% decrease compared with KO, respectively) in the presence of citalopram, suggesting that [(3)H]NE was taken up and released by serotonergic varicosities.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Cox-2 Products


CAS 15307-86-5 Diclofenac

Diclofenac
(CAS: 15307-86-5)

A non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.

CAS 4460-86-0 Asaraldehyde

Asaraldehyde
(CAS: 4460-86-0)

A natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1

CAS 74103-07-4 Ketorolac

Ketorolac
(CAS: 74103-07-4)

A non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively

CAS 287118-97-2 NCX 4040

NCX 4040
(CAS: 287118-97-2)

NCX 4040 is a NO-donating aspirin with anti-inflammatory activity. It can decrease COX-2 expression with IC50 value of 0.13 μM. It can also disrupt proteasome-m...

CAS 40828-46-4 Suprofen

Suprofen
(CAS: 40828-46-4)

A dual COX-1/COX-2 inhibitor

CAS 53-86-1 Indomethacin

Indomethacin
(CAS: 53-86-1)

A nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively

CAS 26159-34-2 Naproxen Sodium

Naproxen Sodium
(CAS: 26159-34-2)

A COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.

CAS 6754-58-1 Xanthohumol

Xanthohumol
(CAS: 6754-58-1)

An inhibitor of COX-1 and COX-2

Chemical Structure

CAS 633-65-8 Berberine hydrochloride

Quick Inquiry

Verification code

Featured Items