Benzyl alcohol - CAS 100-51-6
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Benzyl alcohol, an aromatic alcohol compound, could be found in many sorts of essential oils with the FEMA number: 2137.
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A clear colorless liquid with a pleasant odor. Slightly denser than water. Flash point 194°F. Boiling point 401°F. Contact may irritate skin, eyes, and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals.
(Hydroxymethyl)benzene;alcoolbenzylique;Bentalol;benzalalcohol;Benzalcohol;Benzenemethan-lo;benzenmethanol;Benzoyl alcohol
DMSO: ≥ 1.8 mg/mL
Benzyl alcohol is an aromatic alcohol compound and could be found in many sorts of essential oils and used in the synthesis of Cephalosporolide B.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Boiling Point:
Melting Point:
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1.Development of intranasal nanovehicles of itraconazole and their immunological activities for the therapy of rhinovirus infection.
Lee JJ1, Shim A2, Jeong JY1, Lee SY1, Ko HJ3, Cho HJ4. Colloids Surf B Biointerfaces. 2016 Mar 18;143:336-341. doi: 10.1016/j.colsurfb.2016.03.050. [Epub ahead of print]
Itraconazole (ITZ)-loaded microemulsion (ME) systems for intranasal (IN) delivery were developed for the treatment of human rhinovirus serotype 1B (HRV1B) infection. ITZ was incorporated into the oil-in-water (o/w) ME formulation composed of benzyl alcohol (oil), Cremophor EL (surfactant), Solutol HS15 (cosurfactant), and water. The optimized composition of ME was determined by constructing pseudo-ternary phase diagram. ITZ ME formulation with about 150nm mean diameter and spherical shape was prepared and the solubility of ITZ in blank ME was markedly improved (up to 13.9mg/mL). The initial value of droplet size was maintained with four times dilution in the aqueous buffer and 72h incubation. Released amounts of drug from ME formulation were significantly enhanced compared to drug suspension group (p<0.05). Particularly, ITZ ME group displayed lower levels of inflammatory markers in the lung compared to ITZ suspension group after their IN administration in the HRV1B-infected mouse model (p<0.
2.Spatial distribution of oil depots monitored in human muscle using MRI.
Kalicharan RW1, Baron P2, Oussoren C3, Bartels LW2, Vromans H4. Int J Pharm. 2016 Mar 31;505(1-2):52-60. doi: 10.1016/j.ijpharm.2016.03.064. [Epub ahead of print]
Oil depots are parenteral drug formulations meant for sustained release of lipophilic compounds. According to mass transport models, the drug-release rate from these injections is determined by the surface area of the oil depot. Until now, the size of the surface area of injected depots has not been assessed, however. MRI provides an excellent possibility to distinguish between water and adipose tissue. The aim of this study was to investigate whether MRI can be used to determine the shape and hence the surface area of oil depots in muscle tissue. The developed MRI-scan protocol is demonstrated to be suitable for visualising oil depots. It was applied to determine the surface area of 0.5mL oil, i.m. injected in healthy volunteers. The mean (±RSD) surface area and volume of the depots recovered after injection was 755.4mm2 (±26.5) and 520.1mm3 (±24.6). It is shown that the depot disappearance from the injection site is very variable between volunteers.
3.Pd(0)@UiO-68-AP: chelation-directed bifunctional heterogeneous catalyst for stepwise organic transformations.
Li YA1, Yang S1, Liu QK1, Chen GJ1, Ma JP1, Dong YB1. Chem Commun (Camb). 2016 Apr 1. [Epub ahead of print]
A bifunctional heterogeneous catalyst Pd(0)@UiO-68-AP based on a chelation-directed post-synthetic approach is reported. It exhibits typical heterogeneous catalytic behaviour and can promote benzyl alcohol oxidiation-Knoevenagel condensation in a stepwise way.
4.A new approach to synthesis of benzyl cinnamate: Optimization by response surface methodology.
Zhang DH1, Zhang JY2, Che WC3, Wang Y2. Food Chem. 2016 Sep 1;206:44-9. doi: 10.1016/j.foodchem.2016.03.015. Epub 2016 Mar 7.
In this work, the new approach to synthesis of benzyl cinnamate by enzymatic esterification of cinnamic acid with benzyl alcohol is optimized by response surface methodology. The effects of various reaction conditions, including temperature, enzyme loading, substrate molar ratio of benzyl alcohol to cinnamic acid, and reaction time, are investigated. A 5-level-4-factor central composite design is employed to search for the optimal yield of benzyl cinnamate. A quadratic polynomial regression model is used to analyze the experimental data at a 95% confidence level (P<0.05). The coefficient of determination of this model is found to be 0.9851. Three sets of optimum reaction conditions are established, and the verified experimental trials are performed for validating the optimum points. Under the optimum conditions (40°C, 31mg/mL enzyme loading, 2.6:1 molar ratio, 27h), the yield reaches 97.7%, which provides an efficient processes for industrial production of benzyl cinnamate.
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CAS 100-51-6 Benzyl alcohol

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