Benzoylaconine - CAS 466-24-0
Catalog number: 466-24-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C32H45NO10
Molecular Weight:
603.7
COA:
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Targets:
Others
Description:
Benzoylaconine is an alkaloid in the Chinese traditional medicine Radix Aconiti Lateralis Preparata.
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Purity:
>98%
Synonyms:
Isaconitine; Pikraconitin
MSDS:
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1.Biological activities and pharmacokinetics of aconitine, benzoylaconine, and aconine after oral administration in rats.
Zhang H1,2, Sun S1, Zhang W1, Xie X3, Zhu Z2, Chai Y2, Zhang G1. Drug Test Anal. 2015 Sep 11. doi: 10.1002/dta.1858. [Epub ahead of print]
Aconitine (AC), benzoylaconine (BAC), and aconine (ACN) are three representative alkaloids in Aconitum tubers. Knowing that the drug disposal process in vivo is closely related to the toxicity and efficacy of a drug, it is important to classify the disposal properties of these alkaloids. In this study, the pharmacokinetics of the three alkaloids was investigated. The results showed that the three alkaloids could be quickly absorbed, especially BAC, whose Tmax was 0.31 ± 0.17 h. Their Cmax was 10.99, 3.99, and 4.29 ng·mL-1 respectively, indicating that AC had better absorption than BAC and ACN. Subsequently, we further investigated their absorption mechanism using the Caco-2 cell monolayer model in vitro. The results showed that they were poorly absorbed, and the absorption of AC and BAC was inhibited by P-gp, while the absorption of ACN was in a form of passive diffusion. The t1/2 of AC, BAC and ACN was 1.41, 9.49, and 3.32 h, respectively, indicating that the metabolic or excretion rate of AC was quicker than that of BAC and ACN.
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CAS 466-24-0 Benzoylaconine

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