Benzocaine - CAS 94-09-7
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Not Intended for Therapeutic Use. For research use only.
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Molecular Weight:
Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops
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ethyl 4-aminobenzoate
1. Assembling and de-assembling micelles: competitive interactions of cyclodextrins and drugs with Pluronics
Cecile A. Dreiss,* Ekene Nwabunwanne, Rong Liua and Nicholas J. Brooks. Soft Matter, 2009, 5, 1888–1896
In this work, we solubilised the local anaesthetic lidocaine or benzocaine into F127 micelles at varying concentrations. A simple phase diagram of F127 in the presence of lidocaine shows regions of existence of either a sol or a gel state (Fig. 7). In agreement with previous studies, the incorporation of hydrophobic species into the micelles significantly decreases the gelling point of F127. The diagram obtained with benzocaine is similar, but the gel-domain is extended to lower concentrations of benzocaine. The gelation brought about by the addition of hydrophobic molecules has been explained in terms of an increase in the effective concentration of polymer leading to an association of the micelles into a network, or an entropic drive linked to the disruption of the water structure around the PPO chains.
2. Validated simultaneous determination of antipyrine and benzocaine HCl in the presence of benzocaine HCl degradation product
Hanan A. Merey* and Hala E. Zaazaa. Anal. Methods,2014, 6,6044–6050
Antipyrine (ANT) is 1,5-dimethyl-2-phenyl-4-pyrazolin-3-one; it is a NSAID that can relieve mild to moderate pain. It is available in USP and BP pharmacopeia. The literature survey reveals several analytical methods for the determination of ANT, either in single form or co-formulated with other drugs, including spectrophotometric, chemometric, HPLC, TLC, GC, capillary zone electrophoresis and non-aqueous titration methods. Benzocaine HCl (BEN) is the ethyl ester of 4-amino benzoic acid (ethyl 4-aminobenzoate) in HCl salt used as a local anaesthetic for superficial anaesthesia, for the local and temporal relief of pain related to, among other disorders, buccal affections. Besides being officially available in USP and BP pharmacopeia, BEN was determined by spectrophotometric and HPLC methods. Also, BEN has been analyzed in the presence of its degradation product by HPLC.
3. Flexible SERS active substrates from ordered vertical Au nanorod arrays
A. Martın, J. J. Wangb and D. Iacopino*. RSC Adv.,2014, 4, 20038–20043
We also performed detection of benzocaine by swabbing a surface containing traces of the analyte. Specifically, trace amount of benzocaine were deposited and crushed on a glass slide. A nitrogen gun was used to remove as much benzocaine as possible, leaving only trace amounts. A drop of MeOH was added to a pPET substrate which was swabbed against the glass slide containing benzocaine traces. The pPET was subsequently dried with N2 gun, rinsed again withMeOH and dried, to ensure that only traces amounts were left on the active substrate..
4. Evaluating the non-isothermal crystallization behavior of organic molecules from the undercooled melt state using rapid heat/cool calorimetry
Jared A. Baird, Leonard C. Thomas, Steven R. Aubuchon and Lynne S. Taylor*. CrystEngComm, 2013, 15, 111–119
For example, at a cooling rate of 5 oC min-1 4-biphenyl-methanol crystallized at a degree of undercooling ≈ 9.5 oC, while benzocaine crystallized at a degree of undercooling ≈ 31.9 oC at the same cooling rate. Thus for these two compounds it can be surmised that at a degree of undercooling of ≈ 9.5 oC the relative nucleation and/or growth rates for 4-biphenylmethanol are significantly higher than those for benzocaine, resulting in crystallization being observed at a lower degree of undercooling for the former compound.
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CAS 94-09-7 Benzocaine

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