Benfluorex hydrochloride - CAS 23642-66-2
Catalog number: 23642-66-2
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19H21ClF3NO2
Molecular Weight:
387.82
COA:
Inquire
Targets:
Others
Description:
Benfluorex hydrochloride is a known hypolipidaemic agent with possible glucose-lowering effects. Several clinical studies have shown a reduction in triglyceride and cholesterol levels and a rise in high density lipoprotein (HDL) after treatment with benfl
Purity:
95%
Appearance:
White Solid
Synonyms:
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl benzoate;hydrochloride 1-(2-trifluoromethylphenyl)-2-(benzoyloxyethyl)aminopropane HCl 780 SE benfluorex benfluorex hydrochloride benfluorex hydrochloride, (+-)-isomer benfluorex maleate benfluorex, m
Solubility:
Soluble to 10 mM in H2O
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -104℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Data not available, please inquire.
Boiling Point:
420.5ºC at 760mmHg
Density:
1.183 g/cm3
InChIKey:
NLOALSPYZIIXEO-UHFFFAOYSA-N
InChI:
1S/C19H20F3NO2.ClH/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16;/h2-9,13-14,23H,10-12H2,1H3;1H
Canonical SMILES:
CC(CC1=CC(=CC=C1)C(F)(F)F)NCCOC(=O)C2=CC=CC=C2.Cl
1.Fatal dynamic mitral regurgitation as a presentation of benfluorex-Induced valvular heart toxicity.
Malergue MC1, Bruneval P2, Czitrom D3, Ennezat PV4. Int J Cardiol. 2015 Apr 1;184:549-51. doi: 10.1016/j.ijcard.2015.03.009. Epub 2015 Mar 3.
2.Benfluorex: An active toxin for the development of aortic valve stenosis.
Melloul E1, Bruneval P2, Chavanon O1, Lantuejoul S1, Augier C1, Salvat M1, Maréchaux S3, Tribouilloy C4, Assoun B5, Ennezat PV6. Int J Cardiol. 2015 Feb 15;181:328-30. doi: 10.1016/j.ijcard.2014.11.158. Epub 2014 Nov 26.
3.Operative finding of aortic cusp prolapse in benfluorex-induced aortic regurgitation.
Ennezat PV1, Bruneval P2, Maréchaux S3, Bellemin JP4, Senellart F5, Arnaud-Crozat E6, Ramadan R7, Obadia JF8, Touati G9, Fleury JP6, Tribouilloy C9. Int J Cardiol. 2015;186:231-2. doi: 10.1016/j.ijcard.2015.03.191. Epub 2015 Mar 18.
4.Calcifications in benfluorex-induced valve heart disease: a misknown association.
Plurien F1, Bruneval P, Jobic Y, Iung B, Ennezat PV. Cardiology. 2015;130(2):87-90. doi: 10.1159/000369128. Epub 2015 Jan 20.
Benfluorex, an anorexigenic agent, is recognized to induce noncalcified restrictive valvular regurgitation. We report a well-documented case of a 73-year-old patient who developed heart failure with aortic and mitral regurgitation following benfluorex intake. Echocardiography and peroperative analysis found large mitral annular calcifications and aortic subvalvular calcifications. Pathology confirmed drug-induced valve heart disease (DIVHD). The presence of valvular apparatus calcification should not lead to diagnosis of degenerative valvular disease and a priori preclude the diagnosis of DIVHD.
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CAS 23642-66-2 Benfluorex hydrochloride

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