|Description||Bendamustine hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism.|
|Synonyms||SDX-105 (Cytostasane) HCl|
Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
JNJ-10329670 represents a novel class of immunosuppressive compounds with a highly potent (Ki ~30 nM)
Inositol is a chemical compound found in many foods, especially oranges and cantaloupe. It is well-absorbed and relatively bioavailable. It is a component of me...
Pixantrone is a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topo...
JNJ-2408068 is a potent inhibitor of respiratory syncytial virus (RSV), exhibits potent antiviral activity with 50% effective concentrations (EC50s) of 1.4 and ...
A802715, a methylxanthine derivative, is an anti-tumor agent with a TD50 (toxic dose of 50%) of 0.9-1.1 mM.
Fostriecin sodium salt
Fostriecin sodium salt is a protein phosphatase types 2A (PP2A) and 4 (PP4) inhibitor (IC50 = 1.5 nM and 3 nM, respectively). It also has an inhibitory effect o...
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand. It has been used for research, therapy, and diagnosis of neoangiogenesis. It is also used as a negative co...
Heparin sodium is a sodium salt of heparin which is a naturally-occurring anticoagulant used for anticoagulation for cardiovascular disease. It is an inhibitor ...
Pamidronate disodium pentahydrate
Pamidronate disodium pentahydrate is a nitrogen-containing bisphosphonate, used to prevent osteoporosis.
Midodrine is an α1-receptor agonist and exerts its actions via activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature.
ThioLox is an inhibitor of 15-lipoxygenase-1 (15-LOX-1) with both anti-inflammatory and neuroprotective properties (IC50 value of 12 µM). 15-LOX-1 is involved i...
Adrafinil, prodrug of modafinil, is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention. It is believed to serve a...
A bio-active organic chemical.
Remogliflozin etabonat, pro-drug of remogliflozin, is a SGLT2 inhibitor under development for the treatment of type 2 diabetes. Remogliflozin etabonate is a pr...
4-Hydroxybenzoic Acid Ethyl Ester
4-Hydroxybenzoic Acid Ethyl Ester could be commonly used in cosmetic products as an antimicrobial agent.
Mulberroside A, extracted from the root bark of white mulberry, could reduce P-gp expression and function being along with the activation of PKC and NF-κB. It h...
Navamepent is an inflammation mediator inhibitor and lipid modulator originated by Resolvyx Pharmaceuticals and licensed to Auven Therapeutics in 2011. Treatmen...
CTX-0294885 is a novel broad-spectrum kinase inhibitor. CTx-0294885 exhibits inhibitory activity against a broad range of kinases in vitro. Use of a quantitativ...
Novaluron is a chemical with pesticide properties, belonging to the class of insecticides called insect growth regulators. It inhibits chitin formation, targeti...