Belotecan hydrochloride - CAS 213819-48-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H28ClN3O4
Molecular Weight:
469.96
COA:
Inquire
Targets:
Topoisomerase
Description:
Belotecan hydrochloride, also called as CKD-602 hydrochloride, a Topoisomerase I inhibitor, is the hydrochloride salt of the semi-synthetic and water-soluble camptothecin analogue belotecan with potential antitumor activity.
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
A Topoisomerase I inhibitor
Related CAS:
256411-32-2 (free base)
Synonyms:
7-(2-(N-isopropylamino)ethyl)camptothecin; belotecan; belotecan hydrochloride; CKD 602; CKD-602; CKD602
Solubility:
DMSO: ≥50 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
InChIKey:
SJKBXKKZBKCHET-UQIIZPHYSA-N
InChI:
1S/C25H27N3O4.ClH/c1-4-25(31)19-11-21-22-17(12-28(21)23(29)18(19)13-32-24(25)30)15(9-10-26-14(2)3)16-7-5-6-8-20(16)27-22;/h5-8,11,14,26,31H,4,9-10,12-13H2,1-3H3;1H/t25-;/m0./s1
Canonical SMILES:
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Topoisomerase Products


CAS 1562067-05-3 Banoxantrone D12

Banoxantrone D12
(CAS: 1562067-05-3)

The deuterium labeled banoxantrone which was rationally designed to have anti-tumor activity following bioreduction by tissue cytochrome P450 to AQ4, an active ...

CAS 51264-14-3 Amsacrine

Amsacrine
(CAS: 51264-14-3)

Amsacrine is an antineoplastic agent which can intercalate into the DNA of tumor cells. It also expresses topoisomerase inhibitor activity, specifically inhibit...

CAS 29767-20-2 Teniposide

Teniposide
(CAS: 29767-20-2)

Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).It is in a class of drugs known as podoph...

SW044248
(CAS: 522650-83-5)

SW044248 is a potent and selective Topoisomerase I inhibitor. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortaliz...

CAS 74550-97-3 Bimolane

Bimolane
(CAS: 74550-97-3)

Bimolane is a topoisomerase II inhibitor. It has been widely used as an anti-neoplastic agent and for the treatment of psoriasis in China. Bimolane is also a le...

CAS 151271-53-3 UK-1

UK-1
(CAS: 151271-53-3)

UK-1, a benzoxazol derivative, has been found to a Streptomyces metabolite that could exhibit anticancer activity and topoisomerase II restraination activity.

CAS 213819-48-8 Belotecan hydrochloride

Belotecan hydrochloride
(CAS: 213819-48-8)

Belotecan hydrochloride, also called as CKD-602 hydrochloride, a Topoisomerase I inhibitor, is the hydrochloride salt of the semi-synthetic and water-soluble ca...

CAS 529488-28-6 GENZ-644282

GENZ-644282
(CAS: 529488-28-6)

Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibi...

CP 117227
(CAS: 154531-78-9)

CP 117227, a dibenzocyclohepten derivative, has been found to be a Type II DNA topoisomerase inhibitor that was once developed in studies of anticancer.

CAS 174634-09-4 TAS-103

TAS-103
(CAS: 174634-09-4)

TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be ...

CAS 119413-54-6 Topotecan Hydrochloride

Topotecan Hydrochloride
(CAS: 119413-54-6)

Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes top...

CAS 175519-16-1 Voreloxin Hydrochloride

Voreloxin Hydrochloride
(CAS: 175519-16-1)

Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result...

CAS 174634-08-3 TAS-103

TAS-103
(CAS: 174634-08-3)

TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be ...

CAS 100286-90-6 Irinotecan hydrochloride

Irinotecan hydrochloride
(CAS: 100286-90-6)

Irinotecan Hcl(CPT-11 Hcl) prevents DNA from unwinding by inhibition of topoisomerase 1.

CAS 252979-56-9 Banoxantrone dihydrochloride

Banoxantrone dihydrochloride
(CAS: 252979-56-9)

Banoxantrone dihydrochloride, a bioreductive prodrug, can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor, and ex...

CAS 56420-45-2 Epirubicin

Epirubicin
(CAS: 56420-45-2)

Epirubicin, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. It is clinically active against a broad...

CAS 162706-37-8 Elinafide

Elinafide
(CAS: 162706-37-8)

Elinafide, an isoquinoline derivative, has been found to be a Type II DNA topoisomerase inhibitor that was once developed in anticancer studies.

ABT-719
(CAS: 162829-90-5)

ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies.

CAS 519-23-3 Ellipticine

Ellipticine
(CAS: 519-23-3)

Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Ellipticine is also a natural product, isolated in 1959 from the Australian everg...

CAS 97682-44-5 Irinotecan

Irinotecan
(CAS: 97682-44-5)

Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

Chemical Structure

CAS 213819-48-8 Belotecan hydrochloride

Quick Inquiry

Verification code

Featured Items