|Description||Belinostat is a novel pan-HDAC inhibitor with IC50 of 27 nM, with activity demonstrated in cisplatin-resistant tumors. It inhibits the growth of tumor cells with IC50 from 0.2-0.66 μM in vitro. It shows low activity in A2780/cp70 and 2780AD cells, which are cisplatin and doxorubicin-resistant derivatives of A2780 cells. It could induce apoptosis through PARP cleavage and acetylation of histones H3/H4. It inhibits bladder cancer cell growth, especially in 5637 cells. It could enhance the growth inhibitory activity of docetaxel or carboplatin in OVCAR-3 and A2780 cells. It also shows enhanced tubulin acetylation in ovarian cancer cell lines. It also induces p21WAF1, HDAC core and cell communication genes in mouse bladder tumors in vivo. It is primarily metabolized by UGT1A1 and was given intravenously. It is a histone deacetylase inhibitor drug developed by TopoTarget for the treatment of hematological malignancies and solid tumors. It was approved in July 2014 by the US FDA to treat peripheral T-cell lymphoma.|
|Appearance||Off-white to pink Solid|
|Synonyms||(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide;2-PropenaMide, N-hydroxy-3-[3-[(phenylaMino)sulfonyl]phenyl]-, (2E)-;PXD101;PX105684|
|Solubility||DMSO ≥60mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL|
|Application||Belinostat is a histone deacetylase inhibitor drug and used as the treatment of hematological malignancies and solid tumors.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Melting Point||172 °C | Condition: Solv: ethyl acetate (141-78-6)|
|Density||1.427±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||Belinostat was developed by TopoTarget and was approved in July 2014 by the US FDA to treat peripheral T-cell lymphoma.|
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