Bedaquiline fumarate - CAS 845533-86-0
Catalog number:
845533-86-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C36H35BrN2O6
Molecular Weight:
671.58
COA:
Inquire
Targets:
Antibacterial
Description:
Bedaquiline fumarate is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis. It possesses a unique mechanism of action that disrupts the activity of the mycobacterial adenosine triphosphate synthase. It has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis, however, its side effect profile limits its use against MDR-TB when no other effective regimen can be provided.
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Purity:
>98%
Synonyms:
R403323; Sirturo fumarate; TMC207 fumarate; R207910 fumarate
MSDS:
Inquire
1.Bedaquiline versus placebo for management of multiple drug-resistant tuberculosis: A systematic review.
Charan J1, Reljic T2, Kumar A2. Indian J Pharmacol. 2016 Mar-Apr;48(2):186-91. doi: 10.4103/0253-7613.178839.
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is associated with significant morbidity and mortality. Bedaquiline is the first drug approved for treating MDR-TB.
2.Cost-effectiveness of Bedaquiline for the Treatment of Multidrug-resistant Tuberculosis in the Republic of Korea.
Park HY1, Ku HM2, Sohn HS3, Seo HS4, Yung Lee H5, Hwa Lim K5, Kwon JW6. Clin Ther. 2016 Mar;38(3):655-667.e2. doi: 10.1016/j.clinthera.2016.01.023. Epub 2016 Feb 20.
PURPOSE: Bedaquiline is a new drug used for the treatment of multidrug-resistant tuberculosis (MDR-TB). This study aimed to evaluate the cost-effectiveness of adding bedaquiline to a standard regimen (SR) for treating patients with MDR-TB, including extensively drug-resistant (XDR)-TB, in the Republic of Korea.
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CAS 845533-86-0 Bedaquiline fumarate

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