Beclamide - CAS 501-68-8
Catalog number:
501-68-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H12ClNO
Molecular Weight:
197.66
COA:
Inquire
Targets:
Others
Description:
Beclamide is a chlorinated benzylpropanamide that possesses anticonvulsant activity, has been used for the treatment of tonic-clonic seizyres and has sedative properties.
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Purity:
≥98%
Appearance:
Off-White Solid
Synonyms:
N-Benzyl-3-chloropropionamide; N-benzyl-3-chloropropanamide;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Anticonvulsan
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
90-92 °C
InChIKey:
JPYQFYIEOUVJDU-UHFFFAOYSA-N
InChI:
1S/C10H12ClNO/c11-7-6-10(13)12-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13)
Canonical SMILES:
C1=CC=C(C=C1)CNC(=O)CCCl
1.Metabolism of beclamide, N-benzyl-3-chloropropionamide, in man.
Nicholls PJ, Ross MS, Luscombe DK. Xenobiotica. 1979 Feb;9(2):129-40.
1. Following oral administration of [14C]beclamide to human subjects there was almost complete elimination of radioactivity in the urine within 48 h. 2. Less than 1% of the administered dose was excreted unchanged. 3. The major metabolites were (a) N-(4-hydroxybenzyl)-3-chloropropionamide, (4-hydroxybeclamide; c. 56%), which was eliminated to a small extent in the free form and as a sulphate but mainly as a glucuronide, and (b) hippuric acid (c. 20%). 4. Six minor metabolites were also detected, of which the following were identified: benzoic acid (up to c. 7%), N-(4-hydroxybenzyl-3-chloro-2-hydroxypropionamide, (dihydroxy-beclamide; c. 2%, mostly as a glucuronide) and 4-hydroxybenzoic acid (c. 0.6%, partly as a glucuronide).
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CAS 501-68-8 Beclamide

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