|Description||BD1063 dhydrochloride is a potent and selective antagonist of sigma 1 receptor(Ki= 9.15 nM)with 50-fold more selective over sigma-2(Ki= 449 nM) and >100-fold more selective over 9 other tested neurotransmitter receptors.|
|Brife Description||A potent and selective antagonist of sigma 1 receptor (Ki= 9.15 nM)|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
TC 1 is a high affinity σ1 receptor ligand with selectivity over σ2 receptors (Ki = 10 and 370 nM respectively). TC 1 exhibits low affinity for dopamine (DAT), ...
The hydrochloride salt form of S1RA which is a σ1 receptor antagonist that has been found to have potential effect in pain therapy. It is still under Phase II c...
Siramesine hydrochloride is the hydrochloride salt form of Siramesine. Siramesine is a selective sigma-2 receptor agonist with a potent anticancer activity in v...
BD 1008 dihydrobromide
BD 1008 dihydrobromide is a potent and selective σ receptor antagonist displaying 4-fold selectivity for σ1 over σ2. BD-1008 attenuates the toxicity and stimula...
L-693,403 maleate is the maleate salt of L-693,403, which is a sigma receptor-binding compound. It has excellent selectivity over the dopamine D2 receptor and b...
Siramesine is a selective sigma-2 receptor agonist with a potent anticancer activity in vivo. It was originally devevloped for treating depressant and it has pr...
The sigma-1 (σ1) receptor is an intracellular, non-opioid receptor that is abundantly expressed in the central nervous system as well as peripherally. S1RA is a...
SA-4503 is a potent sigma receptor agonist. SA-4503 may have effects on depressive symptoms such as agitation, loss of interest, and impaired cognition, which a...
NE 100 hydrochloride
NE 100 hydrochloride is a σ1 receptor antagonist with IC50 value of 4.16 nM. It displays antipsychotic activity in vivo.
(±)-PPCC oxalate is a selective sigma (σ) receptor ligand, which is noted to exhibit high affinity for σ1 and also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM re...
4-PPBP, a piperidine derivative, is a σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes. It i...
MIN-101, a novel cyclic amide derivative, is a 5-HT2A and sigma 2 receptor antagonist (Ki= 7.53 nM for 5-HT2A and 8.19 nM for sigma-2, respectively).
PRE-084 Hydrochloride is a selective sigma-1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively). PRE-084 is selective for PCP recepto...
PRE-084 hydrochloride is a high affinity, selective receptors exhibiting neuroprotective effects. Its IC50 value is 44 nM in the sigma receptor assay. In vitro,...
SM-21 maleate is a potent and selective σ2 antagonist that can increase acetylcholine release at central muscarinic synapses. SM-21 is used as a potent analgesi...
Noscapine is a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic ac...
BD1063 dhydrochloride is a potent and selective antagonist of sigma 1 receptor(Ki= 9.15 nM)with 50-fold more selective over sigma-2(Ki= 449 nM) and >100-fold mo...
BD 1047 dihydrobromide
The dihydrobromide salt form of BD-1047, a selective σ1 receptor antagonist, has been found to have antipsychotic effect and could be probably used against schi...
PD 144418 oxalate
PD 144418 oxalate is a very selective sigma 1 agent (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively), devoid of any significant affinity for other re...
Rimcazole dihydrochloride is a small molecule antagonist of the σ-1 receptor (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively).