|Description||BC2059 is a novel β-catenin antagonist and its treatment dose-dependently induced apoptosis of cultured and primary AML BPCs. BC2059 also significantly improved the median survival of immune-depleted mice engrafted with either cultured or primary AML BPCs, showing nuclear expression of β-catenin.|
|Solubility||Soluble in DMSO, not in water|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
PNU 74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). Treatment of human adrenocortical cell lines...
CCT 031374 hydrobromide
CCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription. It was shown to block BIO-induced β-catenin stabilization, and reduce nuclear and cytoso...
KY1220 is a novel inhibitor of the Wnt/ß-catenin pathway, destabilizing both β-catenin and Ras via targeting the Wnt/β-catenin pathway (IC50= 2.1 μM in HEK293 r...
BC2059 is a novel β-catenin antagonist and its treatment dose-dependently induced apoptosis of cultured and primary AML BPCs. BC2059 also significantly improved...
Cardionogen 1 has been found to be a Wnt signaling modulator that could affect cardiomyocyte generation.
KYA1797K is a potent, selective and dual inhibitor of Wnt/β-catenin (IC50= 0.75 µM) that significantly decreases reporter activities for the Wnt/β-catenin and M...
WAY 262611 dihydrochloride is an inhibitor of Dickkopf-1 (DKK1), which antagonizes Wnt/β-Catenin signaling. DKK1 is a soluble inhibitor of Wnt-3a mediated Wnt/β...
WAY-262611 is a wingless beta-Catenin agonist that increases bone formation rate.