BAY 678 - CAS 675103-36-3
Category: Inhibitor
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Molecular Formula:
C20H15F3N4O2
Molecular Weight:
400.35
COA:
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Targets:
Others
Description:
BAY 678 is a cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM) that displays around 2000-fold selectivity for NHE over a panel of 21 other serine proteases.
Brife Description:
HNE inhibitor
Purity:
≥98% by HPLC
Synonyms:
BAY 678; BAY678; BAY-678; 5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
MSDS:
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InChIKey:
PGIVGIFOWOVINL-GOSISDBHSA-N
InChI:
InChI=1S/C20H15F3N4O2/c1-11-17(12(2)28)18(13-6-7-15(9-24)25-10-13)26-19(29)27(11)16-5-3-4-14(8-16)20(21,22)23/h3-8,10,18H,1-2H3,(H,26,29)/t18-/m1/s1
Canonical SMILES:
CC1=C(C(NC(=O)N1C2=CC=CC(=C2)C(F)(F)F)C3=CN=C(C=C3)C#N)C(=O)C
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Chemical Structure

CAS 675103-36-3 BAY 678

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