BAY-1895344 hydrochloride
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C20H22ClN7O
Molecular Weight:
411.89
COA:
Inquire
Targets:
ATM
Description:
BAY-1895344 is a potent, orally available and highly selective ATR inhibitor (IC50= 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). In cellular mechanistic assays BAY 1895344 potently inhibited hydroxyurea-induced H2AX phosphorylation (IC50 = 36 nM).
Synonyms:
(3R)-3-methyl-4-[4-(2-methylpyrazol-3-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl]morpholine;hydrochloride; BAY-1895344 (hydrochloride)
Solubility:
DMSO: ≥ 300 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
InChIKey:
KWQNBYGUBHMRPY-BTQNPOSSSA-N
InChI:
1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25);1H/t13-;/m1./s1
Canonical SMILES:
CC1COCCN1C2=NC3=C(C=CN=C3C4=CC=NN4)C(=C2)C5=CC=NN5C.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related ATM Products


CAS 905973-89-9 CGK733

CGK733
(CAS: 905973-89-9)

CGK733, a thiourea-containing compound, was originally identified as a specific inhibitor of ATR and ATM kinases (IC50 = ~ 200 nM). In prematurely senescent bre...

CAS 1080622-86-1 CP-466722

CP-466722
(CAS: 1080622-86-1)

CP-466722 is a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.

CAS 19545-26-7 Wortmannin

Wortmannin
(CAS: 19545-26-7)

Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces (Penicillium) wortmannii, is a specific, covalent inhibitor of phosphoinositi...

BAY-1895344 hydrochloride

BAY-1895344 is a potent, orally available and highly selective ATR inhibitor (IC50= 7 nM), which potently inhibits proliferation of a broad spectrum of human tu...

CAS 925701-46-8 KU-60019

KU-60019
(CAS: 925701-46-8)

KU-60019 is a potent and reversible inhibitor of ATM kinase with IC50 of 6.3 nM. It is an improved analogue of KU-55933. It exhibits little to no nonspecific ta...

CAS 587871-26-9 KU-55933

KU-55933
(CAS: 587871-26-9)

KU-55933 is an ATM inhibitor,  which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal...

Chemical Structure

CAS  BAY-1895344 hydrochloride

Quick Inquiry

Verification code

Featured Items