BAY-1895344 - CAS 1876467-74-1
Catalog number:
1876467-74-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H21N7O
Molecular Weight:
375.181
COA:
Inquire
Targets:
ATR
Description:
BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor that inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). BAY-1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas, and it is undergoing a phase I clinical trial of safety and tolerability for cancer patients.
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Brife Description:
ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor, ATR, advanced solid tumors and lymphomas
Purity:
≥98 %
Appearance:
Solid Powder
Synonyms:
(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine
Solubility:
Soluble in DMSO.
Storage:
Store in a cool and dry place and at 0-4 ℃ for short term (days to weeks) or -66 ℃ for long term (months to years).
MSDS:
Inquire
Application:
A selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor used for the treatment of advanced solid tumors and lymphomas.
Shelf Life:
2 years
InChIKey:
YBXRSCXGRPSTMW-CYBMUJFWSA-N
InChI:
InChI=1S/C20H21N7O/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25)/t13-/m1/s1
Canonical SMILES:
CN1N=CC=C1C2=C(C=CN=C3C4=CC=NN4)C3=NC(N5[C@H](C)COCC5)=C2
Current Developer:
Bayer
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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