|Description||BAR-501, a UDCA derivative, is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR-501 effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with a EC50 of 1 μM. Besides, protects against development of portal hypertension in rodent models of liver injury and endothelial dysfunction.|
|Brife Description||A selective GPBAR1 agonist|
|Synonyms||3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol; BAR-501; BAR 501; BAR501|
|Solubility||Soluble in DMSO|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).|
|Shelf Life||2 years|
|Boiling Point||527.6±25.0 °C | Condition: Press: 760 Torr|
An agonist of an allosteric binding site on the GABA Receptor subtype A
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