Baohuoside I - CAS 113558-15-9
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
CXCR | Apoptosis Inducer
A regulator of CXCR4 expression
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
A regulator of CXCR4 expression
Light Yellow Solid
3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one; Baohuoside 1; Baohuoside I; Baohuside I; Icariin II; Icariside II
DMSO:32 mg/mL
Please store the product under the recommended conditions in the Certificate of Analysis.
Quality Standard:
Boiling Point:
759.4 °C at 760 mmHg
Melting Point:
Canonical SMILES:
1.Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15.
Yan HM1,2, Song J1,2, Zhang ZH2, Jia XB1,2. Drug Deliv. 2015 Dec 8:1-8. [Epub ahead of print]
Baohuoside I, extracted from the Herba epimedii, is an effective but a poorly soluble antitumor drug. To improve its solubility, formulation of baohuoside I-loaded mixed micelles with lecithin and Solutol HS 15 (BLSM) has been performed in this study. We performed a systematic comparative evaluation of the antiproliferative effect, cellular uptake, antitumor efficacy, and in vivo tumor targeting of these micelles using non-small cell lung cancer (NSCLC) A549 cells. Results showed that the obtained micelles have a mean particle size of around 62.54 nm, and the size of micelles was narrowly distributed. With the improved cellular uptake, BLSM displayed a more potent antiproliferative action on A549 cell lines than baohuoside I; half-maximal inhibitory concentration (IC50) was 6.31 versus 18.28 µg/mL, respectively. The antitumor efficacy test in nude mice showed that BLSM exhibited significantly higher antitumor activity against NSCLC with lesser toxic effects on normal tissues.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related CXCR Products

CAS 266359-83-5 Reparixin

(CAS: 266359-83-5)

An inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation

CAS 472-15-1 Betulinic acid

Betulinic acid
(CAS: 472-15-1)

betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induc...

FC 131
(CAS: 606968-52-9)

CXCR4 antagonist

CAS 697235-39-5 Episilvestrol

(CAS: 697235-39-5)

Episilvestrol is a derivative of Silvestrol, which is a member of flavagline family of natural products from the genus of Aglaia,

VUF 11222
(CAS: 1414376-84-3)

High affinity non-peptide CXCR3 agonist (pKi = 7.2)

TC 14012
(CAS: 368874-34-4)

CXCR4 antagonist; ACKR3 (CXCR7) agonist

(CAS: 862464-58-2)

Navarixin is a potent CXC chemokine receptor 2 (CXCR2) antagonist. It can be used for the treatment of Asthma and Chronic obstructive pulmonary disease. In Dec ...

CAS 960365-65-5 Silvestrol aglycone

Silvestrol aglycone
(CAS: 960365-65-5)

Silvestrol aglycone, extracted from Aglaia foveolata, could induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of e...

VUF 11207 fumarate
(CAS: 1785665-61-3)

Potent ACKR3 (CXCR7) agonist

CAS 266359-93-7 Reparixin L-lysine salt

Reparixin L-lysine salt
(CAS: 266359-93-7)

The efficacy of RPX (tested in a wide range of concentrations (1-1000 nM)) was lower in cells expressing Ile43Val CXCR1 mutant (IC50 values of 0.0056 and 0.08 u...

(CAS: 189036-01-9)

CEP-1612, a dipeptidyl proteasome inhibitor, induces apoptosis and inhibits tumor growth of the human lung cancer cell line A-549 in an in vivo model.

CAS 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5

Ubiquitin Isopeptidase Inhibitor I, G5
(CAS: 108477-18-5)

Ubiquitin Isopeptidase Inhibitor I, G5, a cell-permeable cross-conjugated unsaturated dienone compound, is an apoptosome-independent caspase and apoptosis activ...

CAS 553-21-9 Costunolide

(CAS: 553-21-9)

Costunolide, a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-...

CAS 18457-55-1 Perillyl Alcohol

Perillyl Alcohol
(CAS: 18457-55-1)

Perillyl Alcohol, or POH, a monoterpene derived from the mevalonate pathway in plants, induces apoptosis in colon tumor cells.

(CAS: 568526-77-2)

KRH1636 is an orally active, selective and extremely potent CXC chemokine receptor 4(CXCR4) antagonist. It exhibits a potent and selective anti-HIV-1 activity. ...

(±)-NBI 74330
(CAS: 473722-68-8)

Potent and selective CXCR3 antagonist

(CAS: 4099-30-3)

Desacetylcinobufotalin is apoptosis inducer. shows the inhibition effect to HepG2 cells (IC50 =0.0279μmol/ml) .

CAS 143360-00-3 SMIP004

(CAS: 143360-00-3)

SMIP004 a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells, at low micromolar concentration it upregulated p27 in various prostat...

CAS 1968-05-4 Bis (3-indolyl)methane

Bis (3-indolyl)methane
(CAS: 1968-05-4)

3,3’-Diindolylmethane is a derivative of a phytochemical natural compound found in Brassicaceae(Indole-3-carbinol).It is works as an activator of Chk2 that caus...

CAS 488832-69-5 Elesclomol

(CAS: 488832-69-5)

Elesclomol is a HSP-90 Inhibitor, and is a small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic...

Chemical Structure

CAS 113558-15-9 Baohuoside I

Quick Inquiry

Verification code

Featured Items