Baohuoside I - CAS 113558-15-9
Catalog number: 113558-15-9
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
CXCR | Apoptosis Inducer
A regulator of CXCR4 expression
Brife Description:
A regulator of CXCR4 expression
Light Yellow Solid
3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one; Baohuoside 1; Baohuoside I; Baohuside I; Icariin II; Icariside II
DMSO:32 mg/mL
Please store the product under the recommended conditions in the Certificate of Analysis.
Quality Standard:
Boiling Point:
759.4 °C at 760 mmHg
Melting Point:
Canonical SMILES:
1.Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15.
Yan HM1,2, Song J1,2, Zhang ZH2, Jia XB1,2. Drug Deliv. 2015 Dec 8:1-8. [Epub ahead of print]
Baohuoside I, extracted from the Herba epimedii, is an effective but a poorly soluble antitumor drug. To improve its solubility, formulation of baohuoside I-loaded mixed micelles with lecithin and Solutol HS 15 (BLSM) has been performed in this study. We performed a systematic comparative evaluation of the antiproliferative effect, cellular uptake, antitumor efficacy, and in vivo tumor targeting of these micelles using non-small cell lung cancer (NSCLC) A549 cells. Results showed that the obtained micelles have a mean particle size of around 62.54 nm, and the size of micelles was narrowly distributed. With the improved cellular uptake, BLSM displayed a more potent antiproliferative action on A549 cell lines than baohuoside I; half-maximal inhibitory concentration (IC50) was 6.31 versus 18.28 µg/mL, respectively. The antitumor efficacy test in nude mice showed that BLSM exhibited significantly higher antitumor activity against NSCLC with lesser toxic effects on normal tissues.
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CAS 113558-15-9 Baohuoside I

Baohuoside I
(CAS: 113558-15-9)

A regulator of CXCR4 expression

Chemical Structure

CAS 113558-15-9 Baohuoside I

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