Balofloxacin - CAS 127294-70-6
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Not Intended for Therapeutic Use. For research use only.
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Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.
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1. Ionic liquid based dispersive liquid–liquid microextraction followed by RP-HPLC determination of balofloxacin in rat serum
R. Nageswara Rao,* Ch. Gangu Naidu, Ch. V. Suresh, N. Srinathb and Raju Padiya. Anal. Methods,2014, 6,1674–1683
Accurately weighed 10.0 mg of each balofloxacin and gemifloxacin (IS) (Fig. 1) were separately dissolved in 10.0 mL of MeOH in two volumetric flasks to give 1.0 mg mL-1 individual stock solutions. Working standards of gemifloxacin were prepared by appropriate dilutions of stock solution with MeOH. The working standards were used for the preparation of whole serum calibration standards and also quality control samples. All the stock solutions, calibration standards, and quality control samples were stored at 4 ℃. Calibration standards (range 0.04–10 mg mL-1) were prepared by spiking working standard solutions into serum. These calibration standards were used to test the linearity of themethod. The quality control samples (0.05, 0.1, 2.0 and 7.5 mg mL-1) were prepared by spiking 100 mL of appropriate working standard into 200 mL of serum. The QC samples were used to estimate the extraction recovery (ER) and enrichment factor (EF)s of IL-based DLLME extraction of balofloxacin and gemifloxacin from rat serum.
2. Analysis of trace bromadiolone and brodifacoum in environmental water samples by ionic liquid ultrasound-assisted dispersive liquid–liquid microextraction and LC-MS/MS
Mei-lan Chen, Xiao-hong Chen* and Mi-cong Jin*. Anal. Methods,2014, 6,5879–5885
In 2006, an emerging technique named dispersive liquid–liquid microextraction (DLLME) was developed, which was a novel sample-preparation technique offering high enrichment factors from low volumes of water samples. DLLME has found wide acceptance because of several advantages, including simplicity of operation, rapidity, low cost and ease of method development, which made it available to virtually all analytical laboratories. Today, some studies using DLLME have reported the successful determination of the dye, Brilliant Blue FCF (E133), in different kinds of food and cosmetic samples, linear alkylbenzene sulfonates (LASs) in water samples, ultraviolet filters in water samples, uranium(VI) in water samples, di(2-ethylhexyl) phthalate (DEHP) and its metabolite mono(2-ethylhexyl) phthalate (MEHP) in human urine samples, and balofloxacin in rat serum. DLLME avoids many shortcomings of conventional methods and has been successfully applied for the pre-concentration of organic compounds in environmental and biological fluid samples.
3. The impact of Mycobacterium tuberculosis gyrB point mutations on 6-fluoroquinolones resistance profile: in silico mutagenesis and structure=based assessment
Nikola Minovski,* Marjana Novica and Tom Solmajer. RSC Adv.,2015, 5, 16162–16172
Moreover, the examination of the (T/F)-signed ExpLib compounds selected as correctly/incorrectly positioned within the QBP of each investigated model (3K9Fmod: 84/61, N473Tmod: 40/105, T474Pmod: 42/103, and E475Vmod: 44/101, respectively), identified a total of 27 6-FQ compounds with biological activity values in the range (0.0016 ≤ MICexp [mg mL-1] ≤ 2.000) which are known to be widely used in TB therapy (Table 5). Interestingly, among them only 7 ExpLib compounds (difloxacin, sarafloxacin, clinafloxacin, temafloxacin, moxifloxacin, N-propylciprofloxacin, and balofloxacin) were identifledasnotjustcorrectlypositioned compared to the experimental LFX conformation (see ESI Table S1†), but also active as determined by their biological activity values (MICexp ≤ 1.000 mg mL-1) – a result which additionally allowed the estimation of the 6-FQs resistance, i.e., susceptibility profile for our investigated models (Table 5).
4. Alterations of protein complexes and pathways in genetic information flow and response to stimulus contribute to Escherichia coli resistance to balofloxacin
Hui Li, Jian-Yi Pan, Xuan-Xian Peng*. Mol. BioSyst., 2012, 8, 2303–2311
Cell biochemical processes are performed by a complexome, defined as a set of protein complexes in a cell. Therefore, the identification and characterization of protein complexes is essential to gain a comprehensive understanding of cell functions. Recently, we have presented the first comprehensive characterization of protein complexes of Escherichia coli cleared cell lysates under normal native conditions using 2-D native/ SDS-PAGE based proteomics with co-immunoprecipitation (Co-IP), far-Western blotting, His-tag pull down assays and function analysis, and provided an ideal model system for the investigation of carbohydrate circle and genetic information flow studies in the context of protein–protein interactions. Presently, this approach is used to investigate the altered protein complexes of E. coli in resistance to balofloxacin (BLFX), one of the third generation quinolone antibiotics. Our results demonstrate that not only the modification of the GyrA–GyrB complex, but also the alteration of the other complexes in the genetic information flow, contribute to E. coli resistance to balofloxacin (BLFX). In addition, response to the stimulus pathway is also involved in resistance. These findings broaden and deepen our understanding of bacterial BLFX-resistant mechanisms.
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CAS 127294-70-6 Balofloxacin

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