Baicalein - CAS 491-67-8
Catalog number: 491-67-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H10O5
Molecular Weight:
270.24
COA:
Inquire
Description:
Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora.Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
MSDS:
Inquire
1.γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein.
Yamashita S1, Baba K1, Makio A1, Kumazoe M1, Huang Y1, Lin IC1, Bae J1, Murata M1, Yamada S1, Tachibana H2. Biochem Biophys Res Commun. 2016 Apr 4. pii: S0006-291X(16)30424-7. doi: 10.1016/j.bbrc.2016.03.111. [Epub ahead of print]
Previous studies have identified biomolecules that mediate the physiological actions of food factors, such as amino acids, vitamins, fatty acids, minerals, plant polyphenols, and lactobacilli, suggesting that our bodies are equipped with an innate system that senses which food factors are required to maintain our health. However, the effects of environmental factors on food factor sensing (FFS) remains largely unknown. Tocotorienols (T3s), which belongs to the vitamin E family, possess several physiological functions, including cholesterol lowering and neuroprotective effects. Here, we investigated the effects of naturally abundant γ-T3 on FFS-related gene expressions in melanoma using a DNA chip. Our results showed that γ-T3 increased the expression level of aryl hydrocarbon receptor (AhR), a sensing molecule to plant polyphenol baicalein. The co-treatment with γ-T3 and baicalein enhanced the anti-proliferative activity of baicalein, accompanied by the downstream events of AhR-activation induced by baicalein.
2.Baicalein Reduces Liver Injury Induced by Myocardial Ischemia and Reperfusion.
Lai CC1,2, Huang PH2,3,4, Yang AH5, Chiang SC6, Tang CY1,2, Tseng KW7, Huang CH1. Am J Chin Med. 2016 Apr 24:1-20. [Epub ahead of print]
Baicalein is a component of the root of Scutellaria baicalensis Georgi, which has traditionally been used to treat liver disease in China. In the present study, we investigated baicalein' ability to reduce the liver injury induced by myocardial ischemia and reperfusion (I/R). Myocardial I/R was induced in this experiment by a 40[Formula: see text]min occlusion of the left anterior descending coronary artery and a 3[Formula: see text]h reperfusion in rats. The induced myocardial I/R significantly increased the serum levels of aspartate transaminase (AST) and alanine transaminase (ALT), indicating the presence of liver injury. Hepatic apoptosis was significantly increased. The serum levels of tumor necrosis factor-[Formula: see text] (TNF-[Formula: see text]), interleukin-1[Formula: see text] (IL-1[Formula: see text]), and interleukin-6 (IL-6) were significantly elevated, as was the TNF-[Formula: see text] level in the liver. Intravenous pretreatment with baicalein (3, 10, or 30[Formula: see text]mg/kg) 10[Formula: see text]min before myocardial I/R significantly reduced the serum level increase of AST and ALT, apoptosis in the liver, and the elevation of TNF-[Formula: see text], IL-1[Formula: see text], and IL-6 levels.
3.Baicalein protects isoproterenol induced myocardial ischemic injury in male Wistar rats by mitigating oxidative stress and inflammation.
Kumar M1,2, Kasala ER3, Bodduluru LN3, Dahiya V3, Lahkar M3,4. Inflamm Res. 2016 Apr 12. [Epub ahead of print]
OBJECTIVE: The aim of the present study was to investigate the cardioprotective effects of baicalein, main bioactive constituent from roots of Scutellaria baicalensis and Scutellaria lateriflora, on isoproterenol (ISO) induced acute myocardial infarction model in rats and to explore the underlying mechanisms.
4.Baicalein protects isoproterenol induced myocardial ischemic injury in male Wistar rats by mitigating oxidative stress and inflammation.
Kumar M1,2, Kasala ER3, Bodduluru LN3, Dahiya V3, Lahkar M3,4. Inflamm Res. 2016 Apr 12. [Epub ahead of print]
OBJECTIVE: The aim of the present study was to investigate the cardioprotective effects of baicalein, main bioactive constituent from roots of Scutellaria baicalensis and Scutellaria lateriflora, on isoproterenol (ISO) induced acute myocardial infarction model in rats and to explore the underlying mechanisms.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Chemical Structure

CAS 491-67-8 Baicalein

Quick Inquiry

Verification code

Featured Items