|Description||A member of a potent family of macrocyclic lactones; shares the same mode of action as bafilomycin A1 which has been the analogue of choice in cell biology studies of the role of atpase; a much more stable analogue of bafilomycin A1|
|Purity||>99% by HPLC|
|Solubility||Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.|
A phenylmethylenepyrrolidine first isolated from streptomyces griseolus; an antiprotozoan with antifungal activity; an inhibitor of protein synthesis by binding...
A freely soluble (25 mg/ml) aminoglycoside antibiotic; binds the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthes...
A complex family of macrocyclic lactones containing a highly characteristic spiroketal group; the dominant member of a group of analogues containing a 25-ethyl ...
A unusual polyene originally isolated from an unidentified actinomycete; is related to the phenelfamycins; exhibits activity against gram positive bacteria.
A family of closely related macrocyclic lactone antibiotics produced by streptomyces kitasatoensis; an animal health product for control of gram positive bacter...
The most fully characterised member of a family of phosphate esters of a triene antibiotic; a topoisomerase II inhibitor; selective inhibition of protein phosph...
Thiolutin, a natural dithiol compound, has been found to restrin the bacterial RNA polymerase as well as the angiogenesis caused by tumor cells.
A potent nematocide and acaricide produced by streptoverticillium strains; a potent activator of protein kinase C; a tumour promoting agent; an inducer of colon...
A selective inhibitor of type II fatty acid synthesis (FASII) with IC50 values of 11.4 and 35.3 μg/ml in the S. Aureus and E. Coli FASII assays, respectively, w...
A macrocyclic antibiotic with potent and selective antibacterial activity; a potent inhibitor of the oncogenic transcription factor, foxm1; inhibits foxm1-induc...
A thiopeptide antibiotic isolated from a streptomyces sp.; a potent activator of the tipa gene; a bacterial transcription regulator involved in multidrug resist...
The major analogue of a complex of 16-membered macrocyclic lactones produced by S. Ambofaciens and S. Spiramyceticus; has broad spectrum antibiotic activity
A minor component of the oligomycin complex isolated from selected strains of streptomyces; an inhibitor of mitochondrial F1F0-atpase
Isolated from a streptomyces sp.; nanomolar cytotoxicity to murine P388 leukemia cells; shows antitumour activity in vivo against murine lewis lung carcinoma an...
A 16-membered macrocyclic lactone isolated from streptomyces fradiae; has broad spectrum antibacterial activity; a veterinary pharmaceutical for treatment of ba...
The dominant analogue of a complex of spiroketals isolated from a streptomyces sp.; an inhibitor of the mitogenic activity of EGF; a G1 phase cell cycle inhibit...
An isocoumarin metabolite produced by selected species of streptomyces; a potent inhibitor of cyclic nucleotide phosphodiesterase; also causes dose dependent in...
The major analogue of a family of cyclitol disaccharides; isolated from streptomyces hygroscopicus var. Limoneus; a potent antifungal agent; used to control fun...
A polyaromatic heterocycle containing a rare N-aminoamide; isolated from a streptomyces species; exhibits a broad biological profile with antibiotic, antifungal...
The core structure of a family of dihydroxypyrrolidines produced by several species of streptomyces; potent inhibitors of protein synthesis; a potent growth reg...