Baclofen - CAS 1134-47-0
Catalog number:
B0084-474356
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H12ClNO2
Molecular Weight:
213.66
COA:
Inquire
Targets:
GABA Receptor
Description:
Baclofen, an agonist of GABAB receptor, could be effective as a skeletal muscle relaxant and has been also found to have antispastic effect.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-474356 100 g $198 In stock
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Publictions citing BOC Sciences Products
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Brife Description:
agonist of GABAB receptor, skeletal muscle relaxant
Purity:
>99 %
Appearance:
White or off-white powder
Synonyms:
Baclofen; Lioresal; 4-Amino-3-(4-chlorophenyl)butanoic acid; Baclon; Kemstro
Solubility:
DMSO < 7.8 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Baclofen could be effective as a skeletal muscle relaxant and has been also found to have antispastic effect.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
InChIKey:
KPYSYYIEGFHWSV-UHFFFAOYSA-N
InChI:
InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
Canonical SMILES:
C1=CC(=CC=C1C(CC(=O)O)CN)Cl
1.Safety and Tolerability of Pharmacological Treatment of Alcohol Dependence: Comprehensive Review of Evidence.
Sinclair JM1,2, Chambers SE3, Shiles CJ3,4, Baldwin DS3,5. Drug Saf. 2016 Mar 29. [Epub ahead of print]
Alcohol use disorders (AUD) cause significant morbidity and mortality worldwide, but pharmacological treatments for them are underused, despite evidence of efficacy. Acamprosate, naltrexone, nalmefene and disulfiram are all approved in one or more region for the treatment of AUD. Baclofen currently has a temporary indication in France. Safety considerations for using psychopharmacological treatments in this patient group include the impact of concurrent alcohol consumption at high levels; multiple physical comorbidities that may interfere with pharmacological effects, distribution and metabolism; and concomitant medication for the treatment of comorbid physical and psychiatric conditions. The five drugs, including an extended-release injectable suspension of naltrexone, have different safety profiles that need to be balanced with the treatment objective (initiation or continuation of abstinence, or reduction of drinking), individual patient preferences and comorbid conditions.
2.Baclofen-responsive hiccups after esophageal stenting for malignancy-related dysphagia.
Sharma V1, De A1, Lamoria S1, Lamba BM1. Proc (Bayl Univ Med Cent). 2016 Apr;29(2):150.
Hiccups can have multiple causes, including esophageal lesions. Hiccups after insertion of self-expanding metallic stents have been reported occasionally following stenting for lesions of the gastroesophageal junction. We report a patient who developed hiccups after insertion of a stent for squamous cell carcinoma of the proximal esophagus. The hiccups responded only to the initiation of baclofen therapy.
3.Effects of severe spasticity treatment with intrathecal Baclofen in multiple sclerosis patients: Long term follow-up.
Stampacchia G1, Mazzoleni S2,3, Gerini A1. NeuroRehabilitation. 2016 Apr 6. [Epub ahead of print]
BACKGROUND: Intrathecal Baclofen is available to treat severe generalized spasticity in Multiple Sclerosis (MS) unresponsive to oral drug delivery.
4.Migraine-tic syndrome: Two further case reports.
Hinze S1, Davies P2, Astbury T2, Lane R3. Cephalalgia. 2016 Apr 7. pii: 0333102416644436. [Epub ahead of print]
BACKGROUND: Migraine-tic syndrome was first reported in 2004 in a 44-year-old woman who had concomitant symptoms of both typical trigeminal neuralgia and migraine. We report here two further cases of migraine-tic syndrome and speculate on the relevance of this condition to the pathophysiology of headache.
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Chemical Structure

CAS 1134-47-0 Baclofen

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