Azoramide - CAS 932986-18-0
Catalog number:
932986-18-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H17ClN2OS
Molecular Weight:
308.83
COA:
Inquire
Targets:
Others
Description:
Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It is a dual-function endoplasmic reticulum (ER) modulator in vitro. It improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones to protect cells against ER stress in multiple systems. It regulates ER folding and secretion capacity without inducing ER stress. It might have the protective effects of enhancing chaperone expression and reducing protein synthesis without inducing cytotoxicity and apoptosis. It showed potent antidiabetic activity in two independent mouse models of obesity by protecting pancreatic β cell function against ER stress and improving insulin sensitivity in vivo. It improves glucose homeostasis in mice with genetic obesity and diet-induced obesity.
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Purity:
>98%
Appearance:
White to beige powder
Synonyms:
N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide
Solubility:
DMSO:36mg/mL
Storage:
2-8ºC
MSDS:
Inquire
Application:
Azoramide has antidiabetic activity.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Density:
1⨯+-.0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
VYBFWKKCWTXCQX-UHFFFAOYSA-N
InChI:
InChI=1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19)
Canonical SMILES:
CCCC(=O)NCCC1=CSC(=N1)C2=CC=C(C=C2)Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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