|source\Analogue Sets||Synthetic | Chloramphenicol Analogue Set|
|Description||A semi-synthetic chloramphenicol in which the nitro moiety is replaced with a methylsulphone and the dichloroacetamide is replaced with azidoacetamide; a broad spectrum antibiotic with good activity against gram negative and anaerobic bacteria; acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Azidamfenicol has received little research attention with only a few literature citations.|
|Purity||>99% by HPLC|
|Synonyms||Azidoamphenicol, Leukomycin N|
|Solubility||Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.|
Prepared by acylation of chloramphenicol with succinic anhydride to provide a water soluble pro-drug; represents an alternative pro-drug strategy for chloramphe...
A semi-synthetic chloramphenicol analogue in which the dichloroacetamide is replaced with dibromoacetamide; possesses weak antibiotic activity
A sparingly soluble (1.2 mg/ml) sulfonylurea herbicidal agent
A sparingly soluble (0.776 mg/ml) beta-lactam antibiotic in the carbapenem subgroup; a chemical that inhibits the human enzyme dehydropeptidase; an enzyme capab...
A second generation cephalosporin antibiotic
Unusual nitroaromatic metabolite produced by streptomyces venezuelae; a broad spectrum antibiotic with good activity against gram negative and anaerobic bacteri...
A third generation cephalosporin antibiotic; contains a pivoxil group which increases lipophilicity
Synthesised from thiamphenicol by replacing the 3-hydroxy group with fluorine; a broad spectrum antibiotic with good activity against gram negative and anaerobi...
A diketopiperazine formed by the fusion of tyrosine and proline, reported as a secondary metabolite of fungi and bacteria; capable of activating N-acylhomoserin...
A fourth generation cephalosporin antibiotic
Prepared by acylation of chloramphenicol with palmitic acid; a more hydrophobic drug which should enhance bioavailability; the primary advantage of the ester is...
A semi-synthetic chloramphenicol in which the nitro moiety is replaced with a methylsulphone and the dichloroacetamide is replaced with azidoacetamide; a broad ...
PX-866, an derivative of wortmannin, has been found to be a PI3K inhibitor and probably be effective in some anti-tumor researches. IC50: 0.1-88 nM.
A member of a naturally-occurring complex of chloramphenicol-like acyl nitrophenylpropylamines isolated from corynebacterium hydrocarboclastus; active against g...
A semi-synthetic chloramphenicol prepared by total synthesis from thiophenol in which the nitro moiety of chloramphenicol is replaced by a methylsulphone; a bro...
A nitrofuran antibiotic
A first generation fluoroquinolone antibiotic commonly used in veterinary medicine for enteric infections
An active quorum sensing modulator first recognised in burkholderia pseudomallei; detected in hundreds of bacterial species
Standard Solution T-2 Tetraol Toxin
The 100 ppm acetonitrile solution of T2 Tetraol toxin, a kind of nature type-A trichothecene mycotoxin, could be used as standard solution.
A naturally-occurring co-metabolite of chloramphenicol in streptomyces venezuelae with albeit significantly lower potency; the major product of chloramphenicol ...