Azelastine - CAS 58581-89-8
Catalog number: 58581-89-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H24ClN3O
Molecular Weight:
381.9
COA:
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Targets:
Histamine Receptor
Description:
Azelastine, a phthalazine derivative, is a potent, second-generation, selective, histamine antagonist used as a first line therapy of mild intermittent.
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Purity:
≥98%
Appearance:
white crystal powder
Synonyms:
1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin; 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
An antihistamine and mast cell stabilizer
Quality Standard:
Enterprise Standard/EP/USP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
533.9ºC at 760 mmHg
Density:
1.25 g/cm3
InChIKey:
MBUVEWMHONZEQD-UHFFFAOYSA-N
InChI:
1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3
Canonical SMILES:
CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl
Current Developer:
Muro Pharmaceutical
1.Recent pharmacological developments in the treatment of perennial and persistent allergic rhinitis.
Klimek L1, Mullol J2, Hellings P3, Gevaert P4, Mösges R5, Fokkens W6. Expert Opin Pharmacother. 2016 Apr;17(5):657-69. doi: 10.1517/14656566.2016.1145661. Epub 2016 Mar 3.
INTRODUCTION: Allergic rhinitis (AR) has a major negative impact on patients' quality of life (QoL) and carries a high socio economic burden. This is particularly the case for patients who experience symptoms for extended periods of time (i.e. those with perennial (PAR) or persistent AR (PER), depending on the classification system used). This review covers available pharmacological advances and recent developments in the treatment of PAR or PER.
2.Simultaneous determination of Fluticasone propionate and Azelastine hydrochloride in the presence of pharmaceutical dosage form additives.
Merey HA1, El-Mosallamy SS2, Hassan NY1, El-Zeany BA1. Spectrochim Acta A Mol Biomol Spectrosc. 2016 May 5;160:50-7. doi: 10.1016/j.saa.2016.02.010. Epub 2016 Feb 18.
Fluticasone propionate (FLU) and Azelastine hydrochloride (AZE) are co-formulated with phenylethyl alcohol (PEA) and Benzalkonium chloride (BENZ) (as preservatives) in pharmaceutical dosage form for treatment of seasonal allergies. Different spectrophotometric methods were used for the simultaneous determination of cited drugs in the dosage form. Direct spectrophotometric method was used for determining of AZE, while Derivative of double divisor of ratio spectra (DD-RS), Ratio subtraction coupled with ratio difference method (RS-RD) and Mean centering of the ratio spectra (MCR) are used for the determination of FLU. The linearity of the proposed methods was investigated in the range of 5.00-40.00 and 5.00-80.00μg/mL for FLU and AZE, respectively. The specificity of the developed methods was investigated by analyzing laboratory prepared mixtures containing different ratios of cited drugs in addition to PEA and their pharmaceutical dosage form.
3.Efficacy of topical application of 0.03% tacrolimus eye ointment in the management of allergic conjunctivitis.
Hazarika AK1, Singh PK1. J Nat Sci Biol Med. 2015 Aug;6(Suppl 1):S10-2. doi: 10.4103/0976-9668.166051.
BACKGROUND: Allergic conjunctivitis is commonly observed eye diseases in Sikkim, India due to the abundance of seasonal pollens, environmental pollutants, and house dust. We evaluated the efficacy of topical 0.03% tacrolimus eye ointment in the management of simple allergic conjunctivitis.
4.Cinnamaldehyde is an effective anti-inflammatory agent for treatment of allergic rhinitis in a rat model.
Hancı D1, Altun H2, Çetinkaya EA3, Muluk NB4, Cengiz BP5, Cingi C6. Int J Pediatr Otorhinolaryngol. 2016 May;84:81-7. doi: 10.1016/j.ijporl.2016.03.001. Epub 2016 Mar 7.
OBJECTIVES: The effect of cinnamaldehyde on the treatment of allergic rhinitis (AR) was investigated in rat model.
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Chemical Structure

CAS 58581-89-8 Azelastine

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