|Description||AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. AZD9496 can induce ERα degradation in breast cancer cell lines at picomolar concentrations.|
|B0084-470890||25 mg||$198||In stock|
|Related CAS||1639042-28-6 (maleate)|
|Synonyms||(E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid; AZD9496; AZD-9496; AZD 9496|
|Solubility||Soluble in DMSO, not in water|
|Storage||Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Shelf Life||2 years if stored properly|
Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It ...
PPT, also known as Propyl pyrazole triol, is an ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore a...
Genistin is a derivative of Genistein, which is a PTK inhibitor. Genistin acts as a selective estrogen receptor modulator (SERM). It increases growth of breast ...
(R)-DPN has been found to be an estrogen receptor (ER) β agonist with higher affinity for estrogen receptor.
Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.
Y 134 is a selective estrogen receptor modulator (SERM) with selectivity for ERα over ERβ (Ki = 0.09 and 11.31 nM, respectively). It has no cross-reactivity wit...
MPP dihydrochloride is a selective, high affinity silent antagonist at ERα receptors, with > 200-fold selectivity for ERα over Erβ (Ki= 2.7 and 1800 nM at ERα a...
ERB 041 is a highly selective agonist of the ERβ subtype of the estrogen receptor, displays >200-fold selectivity for ERβ over Erα.
PHTPP, a pyrazolo[1,5-α]pyrimidine-based ligand, is a selective estrogen ERβ receptor antagonist that displays 36-fold selectivity over ERα. This compound has b...
Ethisterone is a progestogen hormone being considered to treat prostate cancer.It was the first orally-active progestin.
Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.
Fulvestrant is an effective inhibitor of the growth of ER-positive MCF-7 (with IC50 of 0.29 nM) but with no effect on the growth of ER-negative BT-20 human brea...
Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding, leading to a reduction in DNA synthesis and cellular ...
Estriol is a metabolite of 17β-estradiol with much lower biological activity. It is the primary estrogen found in the urine. Large quantities of estriol and est...
DY131 is a novel selective agonist of ERRβ and ERRγ, which displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. It could potentiate the...
(Z)-4-Hydroxytamoxifen is a metabolite of Tamoxifen and acts as an estrogen receptor antagonist. It exhibits more than 100-fold affinity over Tamoxifen. (Z)-4-H...
AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. AZD9496 can induce ERα degradation in breast cancer cell l...
Enclomiphene citrateis a non-steroidal estrogen receptor antagonist. It can be used for secondary hypogonadism in overweight men wishing to restore normal testi...
Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is essential for the maintenance of fert...
Quinestriol, also called as Estrovis, is an orally active, long-acting, synthetic estrogen that is effective in hormone replacement therapy.