AZD8797 - CAS 911715-90-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H25N5OS2
Molecular Weight:
403.56
COA:
Inquire
Targets:
CXCR
Description:
AZD8797 is a selective allosteric non-competitive modulator of the human CX3CR1 receptor (Ki= 3.9 nM), binding CX3CR1 and effecting
G-protein signalling and β-arrestin recruitment in a biased way. AZD8797 has a 720 fold selectivity for CX3CR1 receptor over the CXCR2 receptor, a 246-fold selectivity versus hCCR1 and 187-fold versus hCCR2 and no significant antagonism of the CCR4, CCR5, CCR6, CXCR3, and CXCR5 receptors.
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Brife Description:
A selective allosteric non-competitive modulator of the human CX3CR1 receptor (Ki= 3.9 nM)
Synonyms:
(2R)-2-[[2-amino-5-[(1S)-1-phenylethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
Solubility:
DMSO: ≥ 150 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
651.1±65.0 ℃ at 760 Torr
Density:
1.31±0.1 g/cm3
InChIKey:
ZMQSLMZOWVGBSM-GXTWGEPZSA-N
InChI:
1S/C19H25N5OS2/c1-11(2)9-14(10-25)21-16-15-17(22-18(20)27-15)24-19(23-16)26-12(3)13-7-5-4-6-8-13/h4-8,11-12,14,25H,9-10H2,1-3H3,(H3,20,21,22,23,24)/t12-,14+/m0/s1
Canonical SMILES:
CC(C)CC(CO)NC1=NC(=NC2=C1SC(=N2)N)SC(C)C3=CC=CC=C3
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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Chemical Structure

CAS 911715-90-7 AZD8797

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