AZD2932 - CAS 883986-34-3
Catalog number: 883986-34-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H25N5O4
Molecular Weight:
447.49
COA:
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Targets:
PDGFR
Description:
AZD2932 is a new quinazoline ether inhibitor and is a high affinity inhibitor of VEFGR-2 and PDGFR. It has a balanced ~1:1 ratio of activity vs both VEGFR-2 and PDGFRβ. It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases.
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Purity:
>98%
MSDS:
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1.Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
Plé PA1, Jung F, Ashton S, Hennequin L, Laine R, Morgentin R, Pasquet G, Taylor S. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6. doi: 10.1016/j.bmcl.2011.11.019. Epub 2011 Nov 12.
A new series of Quinazoline Ether Inhibitor which potently inhibits VEGFR-2 and PDGFR tyrosine kinases is described here. In vitro, pharmacokinetics and in vivo evaluations led to the selection of AZD2932.
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CAS 883986-34-3 AZD2932

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