AZD2932 - CAS 883986-34-3
Catalog number: B0084-463669
Category: Inhibitor
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Molecular Formula:
C24H25N5O4
Molecular Weight:
447.49
COA:
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Targets:
PDGFR | VEGFR
Description:
AZD2932 is a new quinazoline ether inhibitor and is a high affinity inhibitor of VEFGR-2 and PDGFR. It has a balanced ~1:1 ratio of activity vs both VEGFR-2 and PDGFRβ. It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases.
Purity:
>98%
Synonyms:
AZD2932; AZD 2932; AZD-2932
MSDS:
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InChIKey:
TWYCZJMOEMMCGC-UHFFFAOYSA-N
InChI:
InChI=1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30)
Canonical SMILES:
CC(C)N1C=C(C=N1)NC(=O)CC2=CC=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC
1.Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
Plé PA1, Jung F, Ashton S, Hennequin L, Laine R, Morgentin R, Pasquet G, Taylor S. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6. doi: 10.1016/j.bmcl.2011.11.019. Epub 2011 Nov 12.
A new series of Quinazoline Ether Inhibitor which potently inhibits VEGFR-2 and PDGFR tyrosine kinases is described here. In vitro, pharmacokinetics and in vivo evaluations led to the selection of AZD2932.
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CAS 883986-34-3 AZD2932

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