|Description||This active molecular is a MCHr1 (melanin concentrating hormone receptor 1) antagonist originated by AstraZeneca. AZD1979 has excellent DMPK properties and gave good effects on weight loss in animal model. In Jul 2014, AstraZeneca terminated a phase I trial in Obesity in healthy volunteers in USA after stopping criteria were reached .|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
[Ala17]-MCH is a melanin-concentrating hormone receptor agonist with EC50 values of 17 and 54 nM at MCH1 and MCH2 receptors.
MCH (human, mouse, rat)
MCH is an endogenous melanin-concentration hormone receptor agonist with IC50 values of 0.3 and 1.5 nM at MCH1 and MCH2 receptors respectively. It can increase ...
GW 803430 is a potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). GW 803430 exhibits antiobesity and antidepressan...
SNAP 94847 hydrochloride
SNAP 94847 hydrochloride is a potent and orally bioactive melanin-concentrating hormone receptor 1 (MCH1) antagonist (Ki = 2.2 nM; KD = 530 pM), displaying > 80...
This active molecular is a MCHr1 (melanin concentrating hormone receptor 1) antagonist originated by AstraZeneca. AZD1979 has excellent DMPK properties and gave...
ATC 0175 hydrochloride
The hydrochloride salt form of ATC 0175, which has been found to be a MCHR1, SR-1A and SR-2B inhibitor and probably show anxiolytic and antidepressant activitie...
TC-MCH 7c is a potent, selective and brain-penetrating antagonist of melanin-concentrating hormone receptor 1 (MCH1R) (IC50= 5.6 nM in hMCH1R-expressing CHO cel...