AZD-9291 - CAS 1421373-65-0
Catalog number:
B0084-462147
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C28H33N7O2
Molecular Weight:
499.61
COA:
Certificate of Analysis-AZD-9291-Mereletinib 1421373-65-0 B15L0618  
Targets:
EGFR
Description:
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 µM, respectively).
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Purity:
98%
Appearance:
White to off-white powder
Synonyms:
Mereletinib; EGFR inhibitor; AZD9291; AZD 9291
MSDS:
Inquire
Application:
For research used only
Quality Standard:
Enterprise Standard
Quantity:
Grams-Kilos
Current Developer:
AstraZenca
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 1421373-65-0 AZD-9291

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