AZD-8330 - CAS 869357-68-6
Catalog number:
869357-68-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
MEK
Description:
AZD8330 is an orally active, selective MEK inhibitor with potential antineoplastic activity. AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
Publictions citing BOC Sciences Products
  • >> More
Purity:
0.98
Appearance:
White to off-white Solid
Synonyms:
AZD8330; AZD 8330; ARRY-424704; ARRY-704.
MSDS:
Inquire
Current Developer:
AstraZeneca.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related MEK Products


CAS 1187431-43-1 Trametinib DMSO solvate

Trametinib DMSO solvate
(CAS: 1187431-43-1)

Trametinib is a reversible, selective, allosteric MEK1/MEK2 kinase activity inhibitor with IC50 of 0.7 and 0.9 nM for MEK1 and MEK2.

CAS 1168091-68-6 GDC-0623

GDC-0623
(CAS: 1168091-68-6)

GDC-0623 is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated pro...

CAS 1173097-76-1 U0126-EtOH

U0126-EtOH
(CAS: 1173097-76-1)

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059.

CAS 167869-21-8 PD98059

PD98059
(CAS: 167869-21-8)

PD98059 is a potent and selective inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase). It mediates its inhibitory properties by binding...

CAS 305350-87-2 SL327

SL327
(CAS: 305350-87-2)

SL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion. SL327 had no affect on acquisition, expres...

SMK-17
(CAS: 765958-29-0)

SMK-17 is a MEK1/2 inhibitor. It can inhibit MEK1 kinase activity in a non-ATP-competitive manner and it is highly selective to MEK1 and 2. SMK-17 can inhibit t...

CAS 391210-10-9 PD-0325901

PD-0325901
(CAS: 391210-10-9)

PD-0325901 i a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential an...

CAS 1265916-41-3 BIX02189

BIX02189
(CAS: 1265916-41-3)

Selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases ...

CAS 874101-00-5 RO4987655

RO4987655
(CAS: 874101-00-5)

RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK ...

CAS 923032-38-6 Refametinib R enantiomer

Refametinib R enantiomer
(CAS: 923032-38-6)

Refametinib R enantiomer is a potent, selective and allosteric inhibitor of MEK1/2 in enzyme inhibition assays. It has been reported to inhibit MEK activity and...

CAS 923032-37-5 Refametinib

Refametinib
(CAS: 923032-37-5)

Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor RDEA119...

CAS 334949-59-6 BIX02188

BIX02188
(CAS: 334949-59-6)

CAS 934662-91-6 Cobimetinib racemate

Cobimetinib racemate
(CAS: 934662-91-6)

Cobimetinib racemate is a selective inhibitor of MEK. It is also known as mitogen activated protein kinase kinase (MAPKK) and is a key component of the RAS/RAF/...

CAS 946128-88-7 RO5126766

RO5126766
(CAS: 946128-88-7)

RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-ne...

CAS 2002381-25-9 APS-2-79

APS-2-79
(CAS: 2002381-25-9)

APS-2-79 is a small molecule antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site, and antagonizes oncogenic Ras signalling (I...

CAS 1236699-92-5 Pimasertib

Pimasertib
(CAS: 1236699-92-5)

Pimasertib, also known as AS703026, SAR245509, MSC1936369B, is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineop...

CAS 934660-93-2 Cobimetinib

Cobimetinib
(CAS: 934660-93-2)

cobimetinib, also known as GDC-0973 and XL-518, is an orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1)...

CAS 606143-52-6 Selumetinib

Selumetinib
(CAS: 606143-52-6)

Selumetinib, also known as AZD6244, is an orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated prot...

CAS 871700-17-3 Trametinib

Trametinib
(CAS: 871700-17-3)

Trametinib is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM and no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.

CAS 1035555-63-5 TAK-733

TAK-733
(CAS: 1035555-63-5)

TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor TAK-733 selectively b...

Chemical Structure

CAS 869357-68-6 AZD-8330

Quick Inquiry

Verification code

Featured Items