| Molecular Formula: | |
|---|---|
| Molecular Formula | C58H80N8O8Cl2 |
| Molecular Weight: | |
| Molecular Weight | 1088.21 |
| COA: | |
| COA | Inquire |
| Targets: | |
| Targets | Others |
| Description: | |
| Description | AZD 5582 dihydrochloride is the dihydrochloride salt of AZD 5582, which is a potent inhibitor of cellular (cIAP) inhibitor of apoptosis protein and X-linked (XIAP). Its IC50 values are 15, 21 and 15 nM for cIAP1, cIAP2 and XIAP respectively. It binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. It causes degradation of cIAP1 and cIAP2 and tumor regression, thus induces apoptosis in MDA-MB-231 breast cancer cells. |
| Purity: | |
|---|---|
| Purity | ≥97% by HPLC |
| Synonyms: | |
| Synonyms | AZD 5582 dihydrochloride; AZD5582 dihydrochloride; AZD-5582 dihydrochloride; 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide |
| MSDS: | |
| MSDS | Inquire |
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