AZD 5582 dihydrochloride
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C58H80N8O8Cl2
Molecular Weight:
1088.21
COA:
Inquire
Targets:
Others
Description:
AZD 5582 dihydrochloride is the dihydrochloride salt of AZD 5582, which is a potent inhibitor of cellular (cIAP) inhibitor of apoptosis protein and X-linked (XIAP). Its IC50 values are 15, 21 and 15 nM for cIAP1, cIAP2 and XIAP respectively. It binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. It causes degradation of cIAP1 and cIAP2 and tumor regression, thus induces apoptosis in MDA-MB-231 breast cancer cells.
Publication citing BOC Sciences Products
1. QUARTZ CRYSTAL MICROBALANCE WITH DISSIPATION MEASUREMENTS OF BINDER SWELLING AND SALTS EFFECTS ON PHYSICAL CROSSLINK HYDROGEL
2. A novel, rapid method to compare the therapeutic windows of oral anticoagulants using the Hill coefficient
3. Effect of low and high molecular weights water soluble chitosan on oxidation of whole milk powder
4. Simultaneous determination of neurotoxic shellfish toxins (brevetoxins) in commercial shellfish by liquid chromatography tandem mass spectrometry
5. Removal of acutely hazardous pharmaceuticals from water using multi-template imprinted polymer adsorbent
6. Polyhexamethyleneguanidine phosphate induces cytotoxicity through disruption of membrane integrity

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Purity:
≥97% by HPLC
Synonyms:
AZD 5582 dihydrochloride; AZD5582 dihydrochloride; AZD-5582 dihydrochloride; 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide
MSDS:
Inquire
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