AZD 5582 dihydrochloride
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C58H80N8O8Cl2
Molecular Weight:
1088.21
COA:
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Targets:
Others
Description:
AZD 5582 dihydrochloride is the dihydrochloride salt of AZD 5582, which is a potent inhibitor of cellular (cIAP) inhibitor of apoptosis protein and X-linked (XIAP). Its IC50 values are 15, 21 and 15 nM for cIAP1, cIAP2 and XIAP respectively. It binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. It causes degradation of cIAP1 and cIAP2 and tumor regression, thus induces apoptosis in MDA-MB-231 breast cancer cells.
Purity:
≥97% by HPLC
Synonyms:
AZD 5582 dihydrochloride; AZD5582 dihydrochloride; AZD-5582 dihydrochloride; 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide
MSDS:
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