|Description||AZD 5582 dihydrochloride is the dihydrochloride salt of AZD 5582, which is a potent inhibitor of cellular (cIAP) inhibitor of apoptosis protein and X-linked (XIAP). Its IC50 values are 15, 21 and 15 nM for cIAP1, cIAP2 and XIAP respectively. It binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. It causes degradation of cIAP1 and cIAP2 and tumor regression, thus induces apoptosis in MDA-MB-231 breast cancer cells.|
|Purity||≥97% by HPLC|
|Synonyms||AZD 5582 dihydrochloride; AZD5582 dihydrochloride; AZD-5582 dihydrochloride; 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide|
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