|Description||AZD 3161 is a Nav1.7-voltage-gated-sodium-channel-inhibitor originated by AstraZeneca. Phase-I clinical trials in Pain and Neuropathic pain was discontinued.|
|Synonyms||UNII-403N302X2Y; CHEMBL2069427; 403N302X2Y; 1369501-46-1; AZD-3161; SCHEMBL873691;N-[(3S)-5-(5-methoxypyrazin-2-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxymethyl)pyridine-3-carboxamide|
|Solubility||Soluble in DMSO|
|Application||Neuropathic pain; Pain|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Originator AstraZeneca|
Eleclazine is a selective Sodium channel antagonist. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and en...
Flecainide Acetate is an antiarrhythmic as a Na+ channel blocker that inhibits fast Na+ current in cardiac muscle
T-1095, with potential antidiabetic effect, is an inhibitor of renal Na+-glucose cotransporters that may provide a novel way to treating diabetes.
Proparacaine Hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. IC50(ED50): 3.4 mM.
GS967, also known as GS-458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhyth...
Dibucaine is an anesthetic of the amide type. It is mainly used for surface anesthesia and now restricted to use in spinal and topical anesthesia. It reduced th...
Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders an...
XEN907 is a novel spirooxindole NaV1.7 blocker with IC50 of 3 nM. It shows a further 10-fold increase in potency, which represents a promising structure for fur...
PF-05089771, a Nav1.7 channel blocker, has been studied to have potential effect in the treatment of chronic neuropathic pain. It is still under Phase II clinic...
Sodium Channel inhibitor 1
Sodium Channel inhibitor 1, a 3-Oxoisoindoline-1-carboxamide derivative, is an effective voltage-gated sodium channel blocker that could be used for pain treatm...
Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.
Indecainide is a Sodium channel antagonists originated by Eli Lilly. Treatment for Arrhythmias and Ventricular arrhythmias was discontinued.
Amiloride, a pyrazine derivative potassium-sparing diuretic, is a blocker of sodium channel in renal epithelial cells. Amiloride blocked the low threshold Ca2+ ...
Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage gated sodium channels.
Raxatrigine is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia. It acts as a selective, small-molecule, sta...
Nav1.7 inhibitor is a Voltage-gated sodium channel inhibitor that have probable effect in pain therapy and local anaesthesia.
Vinpocetine is a Phosphodiesterase inhibitor and selective for PDE1. It also blocks voltage-gated Na+ channels.
Phenytoin Sodium is a potent multi-channel blocker, which blocks Na+, K+ and Ca 2+ channels and selectively blocks persistent INaP over shorter INaP actions.
Propoxycaine hydrochloride is the hydrochloride salt form of Propoxycaine used to control the pain of intramuscular injection of penicillin as well as in dentis...
Tetrodotoxin, frequently abbreviated as TTX, is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ...