AZD-3147 - CAS 1101810-02-9
Catalog number: 1101810-02-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H31N5O4S2
Molecular Weight:
517.66
COA:
Inquire
Targets:
mTOR
Description:
AZD-3147 is an extremely potent and selective dual inhibitor of mTORC1 and mTORC2. It exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. It has physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate.
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Purity:
>98%
Appearance:
White solid
Synonyms:
AZD3147;(S)-1-(4-(4-(1-(cyclopropylsulfonyl)cyclopropyl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)-3-(2-hydroxyethyl)thiourea
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
AZD-3147 has physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
696.7±65.0 °C | Condition: Press: 760 Torr
Density:
1.45±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
JWGVUDPAMQEIJU-INIZCTEOSA-N
InChI:
InChI=1S/C24H31N5O4S2/c1-16-15-33-13-11-29(16)21-14-20(24(8-9-24)35(31,32)19-6-7-19)27-22(28-21)17-2-4-18(5-3-17)26-23(34)25-10-12-30/h2-5,14,16,19,30H,6-13,15H2,1H3,(H2,25,26,34)/t16-/m0/s1
Canonical SMILES:
CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C4CC4)C5=CC=C(C=C5)NC(=S)NCCO
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